ArticleDiabetes, obesity & metabolism2026
Uptake and early outcomes of a meal replacement intervention in an ethnically diverse adult population living with obesity and significant comorbidity.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsStructured meal replacement low energy diets (MR-LED) are effective in obesity management, but evidence for individuals of minority ethnic groups or those with BMI >35 kg/m MATERIALS AND
methodsWe evaluated the early effectiveness of a weight management program delivered by a multidisciplinary team within a specialist weight management service. We enrolled three groups: those who had been declined bariatric surgery, young adults with type 2 diabetes (T2D), and people awaiting corneal transplant who had their procedure deferred due to their weight. Individuals were primarily treated with a 12-week MR-LED. Adjunctive obesity medications were available under pre-specified criteria. The present study reports outcomes following the 12-week MR-LED, which was the first phase of a 12 month programme.
resultsOf the 1172 people screened, 482 met inclusion criteria and 128 commenced MR-LED. Most participants (111/128, 87%) had previously been declined bariatric surgery; 11/128 (9%) were young adults with T2D and 6/128 (5%) were awaiting corneal transplant surgery. Ninety-three individuals (73%) were from Pacific or indigenous Māori ethnic groups. The cohort had mean (SD) baseline weight of 145.0 (38.6) kg (BMI 49.9 (11.3) kg/m
conclusionsA 12-week MR-LED intervention delivered in a specialist service achieved clinically meaningful weight loss and improved metabolic and psychological outcomes in a high-risk, multi-ethnic cohort living with higher body weight.
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