Evidence map›Paper›PMID 41714560›Full record

ArticleGeroScience2026

Young blood-induced rejuvenation of neurovascular coupling involves endothelial IGF-1/IGF-1R signaling: evidence from heterochronic parabiosis using endothelial IGF-1R deficient and systemic IGF-1 knockdown mice.

Rafal Gulej, Roland Patai, Siva Sai Chandragiri, Mark Nagykaldi, Evelyn Brunner, Peter Mukli, Dorina Nagy, Kiana Vali Kordestan, Shoba Ekambaram, Santny Shanmugarama and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rafal GulejVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Roland PataiVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Siva Sai ChandragiriVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Mark NagykaldiVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Evelyn BrunnerVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Peter MukliVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Dorina NagyVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Kiana Vali KordestanVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Shoba EkambaramVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Santny ShanmugaramaVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Raghavendra Yelahanka NagarajaVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Andriy YabluchanskiyVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Stefano TarantiniVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Anna CsiszarVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Zoltan UngvariVascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. zoltan.i.ungvari@gmail.com.ORCID http://orcid.org/0000-0002-6035-6039

Funding

Cerebromicrovascular rejuvenation by heterochronic blood exchangeR01AG072295 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2025 to 2025
$433k
Cerebral microhemorrhages and gait abnormalities in agingR01AG055395 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2025 to 2025
$424k
NIA NIH HHS R01 AG055395NIA NIH HHS R01 AG072295
6 · The paper itself

Abstract

Aging is accompanied by progressive impairment of neurovascular coupling (NVC), the mechanism that matches local cerebral blood flow to neuronal activity, contributing to cognitive decline and the development of vascular cognitive impairment and dementia. Exposure to a young systemic milieu through heterochronic parabiosis has been shown to restore NVC in aged mice, suggesting that circulating factors can rejuvenate cerebrovascular function. Yet, the molecular mediators responsible for this effect remain poorly defined. Building on our long-standing research demonstrating that age-related decline in insulin-like growth factor-1 (IGF-1) signaling contributes to cerebrovascular aging and NVC dysfunction, and on recent transcriptomic evidence implicating IGF-1 receptor (IGF-1R) activation in vascular rejuvenation, we hypothesized that the IGF-1/IGF-1R axis plays a role in the young blood-induced restoration of NVC. To test this, we combined heterochronic parabiosis with two complementary transgenic approaches: systemic IGF-1 knockdown (TBG-Cre-AAV8/Igf1

Indexed as

AgingEndothelium, VascularInsulin-Like Growth Factor INeurovascular CouplingParabiosisReceptor, IGF Type 1RejuvenationAnimalsCerebrovascular CirculationMaleMiceMice, Inbred C57BLSignal TransductionIgf1r protein, mouseInsulin-Like Growth Factor IReceptor, IGF Type 1AgingCell non-autonomousCerebral microcirculationCerebrovascular agingEndothelial functionEndothelial IGF-1R deficiencyHeterochronic parabiosisIGF-1 receptor (IGF-1R)Insulin-like growth factor 1 (IGF-1)NeuroendocrineNeurovascular couplingSystemic IGF-1 knockdownVascular cognitive impairment and dementiaVCID

Identifiers

PMID41714560
PMCPMC13356212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.