Evidence map›Paper›PMID 41714804›Full record

ArticleCell death and differentiation2026

Crotonylation of STXBP1 exacerbates seizure susceptibility by impairing GABAergic synaptic transmission.

Yan Liu, Fei Song, Yanlin Guo, Sijiu Xu, Liqin Hu, Ziwei Yuan, Ran Duan, Yuan Meng, Pingyang Ke, Xin Tian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan Liu *Department of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Fei Song *Department of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yanlin Guo *Department of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Sijiu XuDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liqin HuDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ziwei YuanDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ran DuanDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuan MengDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Pingyang KeDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xin TianDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. xintian@cqmu.edu.cn.ORCID 0000-0003-1552-8919
Fei XiaoDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. feixiao81@126.com.ORCID 0000-0002-5981-2922

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82001378National Natural Science Foundation of China (National Science Foundation of China) 82271496National Natural Science Foundation of China (National Science Foundation of China) 82571663
6 · The paper itself

Abstract

Temporal lobe epilepsy (TLE) is the most common and severe form of epilepsy in adults; however, the underlying pathological mechanisms remain unclear. Post-translational modifications (PTMs) of proteins are increasingly recognized to contribute to the development and maintenance of epilepsy; however, the functional significance of lysine crotonylation (Kcr) in epilepsy formation is still unclear. Herein we found that high levels crotonylation promote seizure susceptibility. Through quantitative analysis of global crotonylome in the hippocampus of control and epileptic mice, we identified a significant decrease in K98 crotonylation (K98cr) of syntaxin-binding protein 1 (STXBP1) in epileptic mice hippocampus. In Stxbp1

Indexed as

Munc18 ProteinsSeizuresSynaptic TransmissionAnimalsHippocampusHumansMaleMiceMice, Inbred C57BLMunc18 ProteinsStxbp1 protein, mouse

Identifiers

PMID41714804
PMCPMC13545279

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.