Evidence map›Paper›PMID 41715141›Full record

ArticleParticle and fibre toxicology2026

Alignment of in vitro and in vivo pulmonary inflammation models using crystalline quartz silica.

Isidora Loncarevic, Seyran Mutlu, Martina Dzepic, Sandeep Keshavan, Sandor Balog, Alke Petri-Fink, Fabian Blank, Barbara Rothen-Rutishauser

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isidora LoncarevicAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700, Fribourg, Switzerland.
Seyran MutluDepartment for BioMedical Research (DBMR), Lung Precision Medicine (LPM), University of Bern, Bern, Switzerland.
Martina DzepicDepartment for BioMedical Research (DBMR), Lung Precision Medicine (LPM), University of Bern, Bern, Switzerland.
Sandeep KeshavanAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700, Fribourg, Switzerland.
Sandor BalogAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700, Fribourg, Switzerland.
Alke Petri-FinkAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700, Fribourg, Switzerland.
Fabian Blank *Department for BioMedical Research (DBMR), Lung Precision Medicine (LPM), University of Bern, Bern, Switzerland.
Barbara Rothen-Rutishauser *Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700, Fribourg, Switzerland. barbara.rothen@unifr.ch.

Funding

Swiss National Science Foundation NRP 79 program Nr. 407940_206331 / 1
6 · The paper itself

Abstract

backgroundSystematic in vitro-in vivo comparisons are increasingly used to assess the relevance and predictivity of in vitro lung models for inhalation toxicology and regulatory risk assessment. Here, we compared inflammatory endpoints across established in vitro and in vivo pulmonary models following exposure to crystalline quartz silica particles (DQ

resultsNo increased cytotoxicity or impairment of barrier integrity, as assessed by transepithelial electrical resistance (TEER) and tight junction protein 1 (TJP1) gene expression, was observed 7 days after exposure in vitro, in contrast to clear tissue damage detected in vivo. However, we observed increased release of interleukin (IL)-6 and IL-8, measured at both protein and gene levels. Gene expressions of IL-1β, IL-6, and IL-8 showed positive correlations between the in vitro and in vivo models.

conclusionsBy extending exposure duration and aligning time points, this study identified inflammatory biomarkers that correlate between an in vitro lung model and in vivo data. These findings demonstrate the value of refined in vitro models for assessing particle-induced lung inflammation and support their relevance for hazard assessment.

Indexed as

LungMacrophagesPneumoniaQuartzSilicon DioxideAnimalsCell LineCell SurvivalCoculture TechniquesCytokinesHumansInhalation ExposureTime FactorsZonula Occludens-1 ProteinCytokinesQuartzSilicon DioxideTJP1 protein, humanZonula Occludens-1 ProteinAnimal testingCrystalline quartz silica particlesInflammationInhalation toxicologyIn vitro toxicologyLung cell model

Identifiers

PMID41715141
PMCPMC12918095

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.