Trial reportJournal of cosmetic dermatology2026
The Effect of Microneedling Mesotherapy, Chemical Exfoliation and Combination Therapy on Selected Skin Parameters and Cutibacterium acnes Colonization in Women With Oily Skin.
Trial report in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
backgroundOily skin is characterized by excessive sebum production and increased activity of Cutibacterium acnes.
aimsTo evaluate the effects of mandelic acid exfoliation, microneedle mesotherapy with a sebum-regulating ampoule, and combination therapy on skin parameters and C. acnes activity in women with oily skin.
methodsFifty-five women aged 18-47 were randomly assigned to three groups: microneedle mesotherapy (6 treatments), mandelic acid exfoliation (6 treatments), or combination therapy (3 exfoliations followed by 3 mesotherapy treatments). Skin hydration, sebum level, pH, and gloss were measured using an MPA Courage&Khazaka device. C. acnes activity was assessed indirectly by porphyrin fluorescence with a Visiopor device. Measurements were taken on the cheeks and in the T-zone before treatment (day 1), after three session (day 63), and after six sessions (day 126).
resultsSkin hydration increased significantly in all groups. Mesotherapy reduced sebum in the T-zone only after six treatments, while exfoliation reduced sebum mainly on the cheeks. Combination therapy resulted in the most extensive and stable sebum reduction in both areas. A temporary decrease in pH was observed after mesotherapy, with no pH changes after exfoliation or combination therapy. No significant changes in skin gloss were found. C. acnes colonization increased in the T-zone after mesotherapy, whereas exfoliation and combination therapy significantly reduced all colonization indices, with the strongest effect for combination therapy.
conclusionsMandelic acid exfoliation and microneedle mesotherapy support regulation of sebaceous activity and epidermal barrier function. Combination therapy is therapeutically superior, providing optimal improvement in skin parameters and the most effective reduction of C. acnes activity.
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