Evidence map›Paper›PMID 41716301›Full record

ArticleCell reports. Physical science2026

Advances in peptide nucleic acid for targeting RNA and genomic DNA.

Angana De, Vikas Kumar, W Mark Saltzman, Frank J Slack, Ajit Vikram, Anisha Gupta, Raman Bahal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Physical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angana DeDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
Vikas KumarDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
W Mark SaltzmanDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Frank J SlackDepartment of Pathology, HMS Initiative for RNA Medicine, BIDMC Cancer Center, Harvard Medical School, Boston, MA 02115, USA.
Ajit VikramAbboud Cardiovascular Research Center (ACRC), Fraternal Order of Eagles Diabetes Research Center (FOEDRC), Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Anisha GuptaSchool of Pharmacy, University of Saint Joseph, West Hartford, CT 06117, USA.
Raman BahalDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.

Funding

Targeting microRNAs in the tumor microenvironment with pHLIP conjugated next generation chemically modified PNAsR01CA241194 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SLACK, FRANK J. · 2020 to 2024
$1.9M
Glycopeptide vancomycin reshapes gut microbiota to mediate cardioprotective effects via microRNA-204R01HL167773 · NHLBI · UNIVERSITY OF IOWA · PI Ajit Vikram · 2024 to 2026
$1.5M
NCI NIH HHS R01 CA241194NHLBI NIH HHS R01 HL167773
6 · The paper itself

Abstract

Peptide nucleic acid (PNA) is a synthetic mimic of DNA where the deoxyribose-phosphodiester backbone is replaced with N-(2-aminoethyl) glycine units. The lack of deoxyribose-phosphodiester bonds enhances enzymatic stability and improves binding affinity of PNA with complementary DNA and RNA strands. To enhance target binding, conformational stability, and pharmacological activity, several chemical modifications have been introduced into PNA. Modified PNAs have demonstrated promising preclinical potential as antisense and anti-gene agents, supporting their use in diverse biomedical applications. The limited

Identifiers

PMID41716301
PMCPMC12916000

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.