Evidence map›Paper›PMID 41716322›Full record

ArticleFrontiers in veterinary science2026

Effect of arginine on proliferation of porcine ovarian granulosa cells and steroid hormone synthesis.

Tianrui Zhang, Xintan Lu, Xinyi Wang, Zebei Liu, Xuwen Shao, Rui Han, Dongsheng Che

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianrui Zhang *Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Xintan Lu *Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Xinyi WangKey Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Zebei LiuKey Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Xuwen ShaoKey Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Rui HanKey Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Dongsheng CheKey Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granulosa cells of the ovary (GOC) served as a core component of the follicular microenvironment, playing a crucial role in regulating steroid hormone synthesis and maintaining pregnancy initiation during key reproductive processes. Arginine (Arg) was a key amino acid in follicular fluid that played a potential role in regulating animal reproduction. However, the mechanism by which it controlled the secretion of steroid hormones by ovarian granulosa cells during the initiation of pregnancy remained unclear. In this study, primary porcine ovarian granulosa cells were used to investigate the effects of arginine on cell proliferation, steroid hormone synthesis, and the underlying molecular mechanisms related to pregnancy maintenance. Results showed that the average arginine concentration in follicles measuring 3-8 mm in diameter was 2.7 mM. Based on these measurements, five arginine supplementation groups were established. Findings indicated that the 4.2 mM arginine group exhibited the highest granulosa cell proliferation efficiency, significantly higher than the control group (

Indexed as

cell proliferationgranulosa cellovarypigsteroid hormone

Identifiers

PMID41716322
PMCPMC12913061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.