Evidence map›Paper›PMID 41716343›Full record

ArticleMaterials today. Bio2026

Strontium-luteolin nanoparticles promote M2 macrophage polarization and accelerate acute wound healing via immune microenvironment regulation.

Xiaowen Zheng, Wenqi Wang, Xiaolong Wei, Jianguo Niu, Wei Zhang, Zhenxun Lin, Wei Wei, Shipeng Ning, Min Wang, Xianwen Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A mechanically compliant SrTiOMaterials today. Bio · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaowen ZhengThe Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
Wenqi WangSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
Xiaolong WeiSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
Jianguo NiuSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
Wei ZhangSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
Zhenxun LinThe Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
Wei WeiThe Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
Shipeng NingThe Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
Min WangSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
Xianwen WangSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
Qingjun WeiThe Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise spatiotemporal control of inflammation serves as an effective means to regulate the inflammatory microenvironment and promote wound healing. This study constructed strontium‒luteolin (Sr‒Lut) nanoparticles with a spherical morphology, which demonstrated outstanding radical scavenging capacity through synergistic metal‒ligand effects. Specifically, Sr-Lut efficiently scavenges reactive oxygen species, inhibits the TNF-α/NF-κB and JAK-STAT signaling pathways, promotes M2 polarization, and simultaneously reduces the proinflammatory factor IL-1β and increases the anti-inflammatory factor IL-10. Transcriptomic analysis revealed that Sr-Lut reprogrammed macrophages to downregulate Ccl4 and Retnlg while upregulating extracellular matrix remodeling-associated genes.

Indexed as

Anti-inflammatoryLuteolinMacrophagesNanoparticlesWound

Identifiers

PMID41716343
PMCPMC12914671

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.