ArticleFrontiers in immunology2026
Peripheral blood T-cell subsets combined with EGRIS score predict the need for mechanical ventilation in Guillain-Barré syndrome.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The pathogenesis of Guillain-Barré syndrome (GBS) may involve lymphocyte-mediated immune mechanisms. This study aimed to investigate the relationship between peripheral blood lymphocyte subsets and disease onset, severity, and the need for mechanical ventilation in patients with GBS. Methods: This cohort study included 55 patients with GBS and 58 healthy controls. The association between peripheral blood lymphocyte subsets and the onset and severity of GBS was investigated. Among the GBS patients, 26 were classified into a non-mechanical ventilation group and 29 into a mechanical ventilation group, and the predictive value of peripheral blood lymphocyte subsets for mechanical ventilation was evaluated. Furthermore, the study examined the expression of relevant lymphocyte subsets in the sciatic nerve of experimental autoimmune neuritis (EAN) rat models at different disease stages. Results: ROC curve analysis showed that both CD8 Conclusion: Peripheral blood lymphocyte subsets show potential value in differentiating disease severity and the need for mechanical ventilation in patients with GBS, highlighting the clinical significance of immune cell profiling in risk stratification.
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