Evidence map›Paper›PMID 41716484›Full record

ReviewInternational journal of genomics2026

Epigenetics in B-CLL.

Alexandra Chu, Flavia Soto, Rodrigo Hurtado, Carlos A Tirado

Abstract readReview
In one paragraph

Review in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Epigenetics in B-CLL.International journal of genomics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra ChuThe International Circle of Genetic Studies Project New York Chapter, New York City, New York, USA.
Flavia SotoThe International Circle of Genetic Studies Project Chiclayo Chapter, Chiclayo, Peru.
Rodrigo HurtadoThe International Circle of Genetic Studies Project Chiclayo Chapter, Chiclayo, Peru.ORCID https://orcid.org/0000-0002-3475-2361
Carlos A TiradoThe International Circle of Genetic Studies Project New York Chapter, New York City, New York, USA.ORCID https://orcid.org/0000-0002-5339-5347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-cell chronic lymphocytic leukemia (B-CLL) is the most common hematological malignancy in adults. Its clinical course is heterogeneous, ranging from indolent forms with slow progression to aggressive variants refractory to conventional treatment. In recent years, it has been shown that epigenetic alterations, such as DNA methylation, histone modifications, and regulation by noncoding RNAs, especially microRNAs (miRNAs), play a central role in the prognosis of this disease. For this reason, the analysis of epigenetic mechanisms has become an essential approach both to understand the progression of B-CLL and to predict therapeutic response and patient survival.

Identifiers

PMID41716484
PMCPMC12914334

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.