Evidence map›Paper›PMID 41716572›Full record

ArticlePsychoradiology2026

Altered dynamic functional connectivity of orbitofrontal cortex underlies olfactory and cognitive impairment in late-life depression.

Ben Chen, Shuang Liang, Ting Su, Youxuan Zheng, Wei He, Huarong Zhou, Qiang Wang, Mingfeng Yang, Gaohong Lin, Danyan Xu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ben ChenThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Shuang LiangThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Ting SuThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Youxuan ZhengThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Wei HeThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Huarong ZhouThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Qiang WangThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Mingfeng YangThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Gaohong LinThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Danyan XuThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Yunheng ChenThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Jiafu LiThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Qin LiuThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Kexin YaoThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Zhangying WuThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Min ZhangThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Le HouThe First Affiliated Hospital, Guangzhou University of Chinese Medicine, Department of Psychological Sleep, Guangzhou, China, 510405.
Yueyang ZhangGuangzhou Medical University, Guangzhou, Guangdong, China, 511436.
Xiaomei ZhongThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Yuping NingThe Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.ORCID https://orcid.org/0000-0002-5727-2782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Late-life depression (LLD) and odor identification (OI) dysfunction are risk factors for dementia, but the underlying neural mechanisms remain unclear. This study investigated dynamic functional connectivity (dFC) in olfactory brain regions of LLD patients with and without OI dysfunction and examined how dFC moderates the OI-cognition link. Methods: Resting-state functional magnetic resonance imaging data were acquired from 51 LLD patients with OI deficits (LLD-OID), 59 LLD patients without deficits (LLD-noOID), and 51 healthy controls (HC). A sliding-window approach (50 TR width, 1 TR step) was used to estimate dFC variability between the orbitofrontal cortex (OFC) and the whole brain. Bayesian regression and moderation analyses assessed associations among OFC dFC, OI scores, and cognitive measures. Results were robust across window sizes. Results: Compared to LLD-noOID and HC, LLD-OID showed decreased OFC-left inferior frontal gyrus dFC variability ( Conclusion: LLD patients with OI dysfunction exhibited more disrupted dFC in secondary olfactory regions compared with those without OI dysfunction. Dynamic OFC-MFG disconnectivity may index vulnerability to cognitive decline and dementia risk in LLD patients.

Indexed as

Alzheimer’s diseasecognitive impairmentdynamic functional connectivitylate-life depressionodor identificationorbitofrontal cortex

Identifiers

PMID41716572
PMCPMC12916006

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.