Evidence map›Paper›PMID 41716672›Full record

ArticleBioactive materials2026

Enzyme responsive antimicrobial hyaluronan-nanocellulose hybrid wound dressings for the treatment of infected wounds.

Elisa Zattarin, Wasihun Bekele Kebede, Zeljana Sotra, Rozalin Shamasha, Annika Starkenberg, Valentina Guerrero-Florez, Lalit Pramod Khare, Torbjörn Bengtsson, Hazem Khalaf, Emma M Björk and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisa ZattarinLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.
Wasihun Bekele KebedeLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.
Zeljana SotraCenter for Disaster Medicine and Traumatology, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85, Linköping, Sweden.
Rozalin ShamashaCenter for Disaster Medicine and Traumatology, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85, Linköping, Sweden.
Annika StarkenbergCenter for Disaster Medicine and Traumatology, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85, Linköping, Sweden.
Valentina Guerrero-FlorezDivision of Nanostructured Materials, Department of Physics, Chemistry and Biology (IFM), Linköping University, SE-58183, Linköping, Sweden.
Lalit Pramod KhareLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.
Torbjörn BengtssonDepartment of Microbiology, Immunology and Reproductive Science, School of Medical Sciences, Örebro University, SE-70362, Örebro, Sweden.
Hazem KhalafDepartment of Microbiology, Immunology and Reproductive Science, School of Medical Sciences, Örebro University, SE-70362, Örebro, Sweden.
Emma M BjörkDivision of Nanostructured Materials, Department of Physics, Chemistry and Biology (IFM), Linköping University, SE-58183, Linköping, Sweden.
Jonathan RakarCenter for Disaster Medicine and Traumatology, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85, Linköping, Sweden.
Johan P E JunkerCenter for Disaster Medicine and Traumatology, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85, Linköping, Sweden.
Daniel AiliLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound infections pose a substantial clinical challenge and an escalating healthcare burden, further complicated by the rapid increase in multidrug-resistant bacteria. Antimicrobial peptides (AMPs) offer an alternative to conventional antibiotics, but their rapid degradation, hemolytic activity, and potential cytotoxicity complicate systemic delivery and can have negative impact on wound healing. Here we show a bacterial nanocellulose hyaluronan (BC-HA) hybrid hydrogel wound dressing functionalized with mesoporous silica nanoparticles (MSNs) for localized, enzyme responsive delivery of a sequence optimized antimicrobial peptide (SOAP) for treatment of infected wounds. The dressings provide moisture retention and excellent skin conformability while enabling infection-triggered AMP release by bacterial and host proteases.

Indexed as

Antimicrobial peptidesHyaluronic acidNanocelluloseWound dressingWound infections

Identifiers

PMID41716672
PMCPMC12914817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.