ArticleMediators of inflammation2026
Association Between CBC-Derived Inflammatory Indicators and 28-Day Mortality in Patients With Coronary Heart Disease and Diabetes Mellitus: A Cohort Study From the MIMIC-IV Database.
Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Coronary heart disease (CHD) remains the leading global cause of death; concomitant diabetes mellitus (DM) doubles short-term mortality, largely through chronic low-grade inflammation. Inexpensive, bedside complete blood count (CBC)-derived inflammatory indices (NLR, MLR, PLR, SII, SIRI, and AISI) predict outcomes in CHD or DM alone, but their utility in comorbid patients is unclear. Methods: Retrospective cohort study of CHD-DM patients from Medical Information Mart for Intensive Care-IV (MIMIC-IV; 2008-2022), split into training (2017-2022, Results: Mortality was 10.6% (training) and 11.9% (validation). All indices showed independent, dose-dependent associations with mortality (e.g., training MLR per 1-SD: HR = 1.49, 95% CI = 1.37-1.61), discrimination was good (training AUC 0.767, C-index 0.752; validation AUC 0.755, C-index 0.746), and calibration was excellent. Spearman correlation showed moderate-to-strong interindex correlations (e.g., MLR-SIRI: Conclusions: Six CBC-derived indices independently predict 28-day mortality in critically ill CHD-DM patients, with PLR and MLR showing superior predictive weight, and can be used for rapid, cost-free bedside risk stratification.
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