Evidence mapPaperPMID 41716691Full record

ArticleJournal of pathology informatics2026

Comparison of digital displays for efficient diagnosis and accuracy.

Monika Lamba Saini, Amanda Hemmerich, Anna Banach-Ovens, Hannah Manssens, Robbie Dougan, Tom Kimpe, John D Cochran

Abstract read
In one paragraph

Article in Journal of pathology informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Monika Lamba SainiADC Therapeutics, iHub, Imperial College White City Campus, London W12 0BZ, UK.
Amanda HemmerichIQVIA Laboratories, The Alba Campus, Rosebank, Livingston EH54 7EG, UK.
Anna Banach-OvensIQVIA Laboratories, The Alba Campus, Rosebank, Livingston EH54 7EG, UK.
Hannah ManssensBarco NV, Healthcare Division, Beneluxpark 21, 8500 Kortrijk, Belgium.
Robbie DouganIQVIA Laboratories, The Alba Campus, Rosebank, Livingston EH54 7EG, UK.
Tom KimpeBarco NV, Healthcare Division, Beneluxpark 21, 8500 Kortrijk, Belgium.
John D CochranIQVIA Laboratories, The Alba Campus, Rosebank, Livingston EH54 7EG, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Digital pathology is transforming diagnostic workflows by enabling the interpretation of whole-slide images on digital displays, offering advantages in remote diagnostics, efficiency, and integration with computational tools. However, diagnostic reliability depends not only on scanner and software quality but also on the performance of the display systems used for image review, as well as on environmental and ergonomic factors. This study evaluated the impact of display quality on diagnostic accuracy by comparing a medical-grade, professional-grade, and consumer-grade display against conventional light microscopy. Nineteen hematoxylin and eosin (H&E) and 19 immunohistochemistry (IHC) slides were assessed by two board-certified pathologists across all modalities. The medical-grade display achieved perfect concordance with microscopy for H&E slides and was rated highest for image clarity, color fidelity, and luminance stability. In contrast, the professional- and consumer-grade displays showed lower concordance (85-95%) and received inferior subjective evaluation. For IHC slides, both observers achieved 100% concordance for HER2 and AMACR markers across all displays. One discordant MLH1 case was noted on the medical-grade display for one observer out of five cases. Although MLH1 is consistently analyzed alongside other MSI markers, this isolated discrepancy precludes firm conclusions about display performance for this marker. These findings highlight the importance of clinically validated displays with automated calibration and quality assurance mechanisms to ensure consistent diagnostic performance. As digital pathology becomes increasingly integrated with remote workflows, establishing minimum performance standards for display systems will be essential to safeguard diagnostic accuracy, reproducibility, and patient safety in clinical practice.

Indexed as

Color fidelityDiagnostic accuracyDigital pathologyMedical-grade displayWhole-slide imaging

Identifiers

PMID41716691
PMCPMC12914843

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.