ArticleNature. Mental health2024
Early detection of dementia with default-mode network effective connectivity.
Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Age-Related Hearing Loss on Brain Connectivity and Cognitive Performance: A Systematic Review.Trends in hearingPooled it
- Sleep Fragmentation and Sleep Stages 1 and 2 Are Associated With Amyloid-Beta Burden in Cognitively Normal Older Adults.Journal of sleep research · 2026Trial
- Associations of visceral adipose tissue metabolism with DMN-centered cross-network metabolic expression concordance and cognitive impairment in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2026Article
- From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- From MRI to 3D printing: a tangible neuroeducational tool for visualizing hippocampal morphology and Alzheimer's disease progression.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Hyperbolic Kernel Graph Neural Networks for Neurocognitive Decline Analysis From Multimodal Brain Imaging.IEEE transactions on pattern analysis and machine intelligence · 2026Article
- Cortical gradient compression links cognition and transcriptomic signatures in primary angle-closure glaucoma.Communications biology · 2026Article
- Bidirectional prognostic predictions of conversion and reversion in amnestic mild cognitive impairment.GeroScience · 2026Article
- The Role of Transcranial Magnetic Stimulation for the Treatment of Alzheimer's Disease: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson's Disease-Like Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A multimodal sleep foundation model for disease prediction.Nature medicine · 2026Article
- Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Interpretable multimodal learning for integrating neuroimaging and genetic data in Alzheimer's disease.Frontiers in radiology · 2026Article
- Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities.Frontiers in aging neuroscience · 2026Article
- ScaleSpecter: a frequency-aware multi-scale patch framework for robust physiological classification under non-stationarity.Frontiers in human neuroscience · 2026Article
- The Impact of Insulin Resistance on Grey Matter Changes Along the Alzheimer's Disease Continuum Insulin Resistance and Grey Matter in AD.medRxiv : the preprint server for health sciences · 2025Article
- Longitudinal tractography of the mouse corpus callosum reveals topographical order and differences due to sex and aging.Brain structure & function · 2025Article
- Subjective sleep characteristics in non-demented adults: domain-specific associations with multimodal Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Investigating Disruptions in Information Flow due to Sickle Cell Disease Using Granger Causality.Human brain mapping · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Altered functional connectivity precedes structural brain changes and symptoms in dementia. Alzheimer's disease is the largest contributor to dementia at the population level, and disrupts functional connectivity in the brain's default-mode network (DMN). We investigated whether a neurobiological model of DMN effective connectivity could predict a future dementia diagnosis at the single-participant level. We applied spectral dynamic causal modeling to resting-state functional magnetic resonance imaging data in a nested case-control group from the UK Biobank, including 81 undiagnosed individuals who developed dementia up to nine years after imaging, and 1,030 matched controls. Dysconnectivity predicted both future dementia incidence (AUC = 0.82) and time to diagnosis (
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.