RFX6 expression is central to the development and function of the neuroendocrine compartments of the pancreas and intestine and strongly affects diabetes risk.
Thomas S R Bate, Yuanhao Huang, Xin Luo, Diane C Saunders, John T Walker, Vivek Rai, Stephen C J Parker, Jie Liu, Marcela Brissova
Review in Diabetology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 · Who and what money
Authors and funding
9 authors.
Thomas S R BateDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 USA.
Yuanhao HuangGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2218 USA.
Xin LuoGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2218 USA.
Diane C SaundersDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 USA.
John T WalkerDivision of Endocrinology and Diabetes, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104 USA.
Vivek RaiGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2218 USA.
Stephen C J ParkerGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2218 USA.
Jie LiuGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2218 USA.
Marcela BrissovaDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 USA.ORCID 0000-0002-4999-3280
Funding
Human Pancreas Analysis Program for Type 1 Diabetes - HPAP-T1DU01DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MARK A. ATKINSON, KLAUS H KAESTNER · 2021 to 2026
$46.8M
The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
Penn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
PanKbase: a community hub for integrated pancreas knowledgeU24DK138515 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marcela Brissova, Jean-Philippe Cartailler · 2024 to 2026
$11.3M
Human Pancreas Analysis Program-T2DU01DK123716 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., BOTTINO, RITA · 2019 to 2024
$6.6M
Integrative analysis of multi-omic signatures and cellular function in human pancreas across developmental timeline at single-cell spatial resolutionU01DK135017 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRISSOVA, MARCELA, CAICEDO, ALEJANDRO · 2022 to 2025
$3.8M
Multi-omic genetic regulatory signatures underlying tissue complexity of diabetes in the pancreas at single-cell spatial resolutionR01DK129469 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRISSOVA, MARCELA, LIU, JIE · 2022 to 2025
Transcription factors are central to the developmental and functional regulation of cells through co-ordination of gene expression via interaction with the genome. RFX6 is a winged-helix transcription factor whose expression is highly specific to the pancreas and gastrointestinal tract. Recent developments have highlighted an association between RFX6 and Type 2 Diabetes (T2D), which affects over 500 million people throughout the world. RFX6 controls development in both the pancreas and the gastrointestinal tract, where it is required for the differentiation of islet endocrine and enteroendocrine cells. Coding and non-coding
Indexed as
Islets of langerhansMaturity onset diabetes of the youngMonogenic diabetesPancreasRFX6Type 2 diabetes
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
RFX6 expression is central to the development and function of the neuroendocrine compartments of the pancreas and intestine and strongly affects diabetes risk. · full record | Socratic