ReviewiScience2026
The mechanism and clinical research of vagus nerve electrical stimulation in the treatment of myocardial ischemia-reperfusion injury.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vagus nerve stimulation (VNS), as a neuromodulation therapy, has shown promising prospects in the treatment of myocardial ischemia-reperfusion injury (MIRI) following myocardial infarction (MI). MIRI can exacerbate secondary damage to post-ischemic myocardial tissue. VNS can alleviate MIRI by enhancing vagal nerve activity. In preclinical studies, VNS exerts cardioprotective effects through multi-target synergistic regulation: inhibiting inflammatory cascades through the cholinergic anti-inflammatory pathway (CAP) and vagus nerve-spleen pathway, improving mitochondrial function, resisting oxidative stress, suppressing cardiomyocyte apoptosis, and regulating autonomic nerves to reduce arrhythmias risk. This review explores the interactions between the aforementioned mechanisms, rarely addressed in prior studies. Furthermore, this review summarizes relevant clinical studies, where VNS significantly reduces myocardial injury markers and arrhythmia incidence. However, VNS still faces clinical application challenges including unstandardized parameter and operation standards and insufficient clinical evidence. This review aims to bridge preclinical and clinical research, providing a reference for VNS clinical application in MIRI.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.