Evidence map›Paper›PMID 41717003›Full record

ArticleiScience2026

Increased neuronal activity restores circadian function in Drosophila models of C9orf72-ALS/FTD.

Sho Inami, Benjamin P Jenny, Oghenerukevwe Akpoghiran, Sara I Gallagher, Alexandra K Strich, Ayako Tonoki, Davide Trotti, Aaron R Haeusler, Kyunghee Koh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sho InamiDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Benjamin P JennyDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Oghenerukevwe AkpoghiranDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Sara I GallagherDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Alexandra K StrichDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Ayako TonokiDepartment of Biochemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Davide TrottiDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Aaron R HaeuslerDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Kyunghee KohDepartment of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Funding

The pathogenic relationship between neuronal activity and C9orf72-linked neurodegenerationR01NS114128 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI Aaron Raymond Haeusler · 2024 to 2024
$537k
Molecular pathways linking frontotemporal dementia and circadian dysfunctionR21NS135762 · THOMAS JEFFERSON UNIVERSITY · 2025 to 2025
$195k
NINDS NIH HHS R01 NS114128NINDS NIH HHS R21 NS135762NINDS NIH HHS RF1 NS114128
6 · The paper itself

Abstract

Circadian rhythm disruptions are common across neurodegenerative diseases, but their link to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remains unclear. The

Indexed as

Cellular neuroscienceSystems neuroscience

Identifiers

PMID41717003
PMCPMC12915250

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.