ArticleFrontiers in nutrition2026
Prognostic impact of sarcopenia on 5-year overall and progression-free survival in lung cancer patients: a prospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Sex-stratified prognostic value of low skeletal muscle index in advanced non-small cell lung Cancer: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Skeletal muscle dysfunction induced by cancer immunotherapy: mechanistics insights and surgical implications.Frontiers in immunology · 2026Review
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5 authors.
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Abstract
Background: Sarcopenia is increasingly recognized as a critical prognostic factor in cancer patients, particularly in lung cancer, However, currently the relationship between Sarcopenia and lung cancer prognosis was primarily assessed using imaging modalities such as CT scans and its impact on outcomes in Chinese lung cancer patients, assessed using comprehensive Asian diagnostic criteria, remains underexplored. This study aimed to evaluate the association between Sarcopenia and tumor prognosis and outcome in lung cancer patients. Methods: A prospective cohort of 403 lung cancer patients admitted to Huadong Hospital (2020-2025) was analyzed. Sarcopenia was diagnosed using Asian Working Group for Sarcopenia (AWGS) criteria, combining muscle mass (bioelectrical impedance analysis), handgrip strength, and gait speed. Survival outcomes (overall survival [OS] and progression-free survival [PFS]) were compared between sarcopenic and non-sarcopenic groups using Kaplan-Meier and univariate and multivariate Cox regression analyses were used to identify independent predictors of OS and PFS. Results: Sarcopenia was identified in 43.2% of patients (174/403). Compared with non-sarcopenic patients, sarcopenic patients had significantly shorter median OS (13.2 vs. 43.3 months; Conclusion: Sarcopenia is associated with reduced overall survival time and progression-free survival in lung cancer patients. Sarcopenia is an independent predictor of poor survival particularly in specific high-risk subgroups. When assessing for sarcopenia it is crucial to include assessment of muscle function in evaluating the prognosis of lung cancer.
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