Evidence map›Paper›PMID 41717079›Full record

ReviewBiochemistry and biophysics reports2026

The crosstalk between blood-brain barrier and neural cells: bidirectional regulation of brain function and pathology.

Manling Ju, Haozhou Shen, Xiaobao Zhang, Mi Tian, Li Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manling JuDepartment of Anesthesiology, surgery and pain management & Key Laboratory of Clinical Science and Research, Zhongda Hospital Southeast University, Southeast University School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, PR China.
Haozhou ShenDepartment of Anesthesiology, surgery and pain management & Key Laboratory of Clinical Science and Research, Zhongda Hospital Southeast University, Southeast University School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, PR China.
Xiaobao ZhangDepartment of Anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu Province, PR China.
Mi TianDepartment of Anesthesiology, surgery and pain management & Key Laboratory of Clinical Science and Research, Zhongda Hospital Southeast University, Southeast University School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, PR China.
Li ZhangDepartment of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) serves as a crucial interface between the circulatory system and the central nervous system (CNS), playing a fundamental role in preserving normal brain function and homeostasis.The BBB closely interacts with various neural cells. However, the bidirectional communication between the BBB and neural cells remains incompletely understood. This review investigates the interactions between BBB and neural cells- pericytes neurons, astrocytes, microglia, oligodendrocytes and oligodendrocytes-specifically examining their functions in maintaining BBB structural integrity and barrier function. We further summarize the molecular mechanisms underlying BBB dysfunction in neurological diseases and highlight the role of BBB-neural cell crosstalk in these conditions. Moreover, we emphasize the importance of further studies to clarify how neural cells precisely regulate BBB integrity, tailor individualized treatment strategies, and improve outcomes for neurological disorders. Such advancements would provide valuable insights for both ongoing research and clinical practice.

Indexed as

Blood-brain barrierCellular interactionsNeural cellNeuroinflammationNeurological diseases

Identifiers

PMID41717079
PMCPMC12914248

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.