Evidence map›Paper›PMID 41717082›Full record

ArticleBiochemistry and biophysics reports2026

Anti-cancer effect of palmitic acid against the endometrial cancer progression via inducing ferroptosis.

Shuting Lan, Xiaomei Sun, Qiyuan Bo, Suriguga Wang, Yifan Qin, Jianying Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuting LanBaotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014040, China.
Xiaomei SunBaotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014040, China.
Qiyuan BoBaotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014040, China.
Suriguga WangBaotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014040, China.
Yifan QinBaotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014040, China.
Jianying MaoDepartment of Gynecology and Obstetrics, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, 010017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The critical role of metabolic reprogramming as a potential therapeutic target in the management of endometrial cancer (EC) progression requires further investigation. This study investigated the anti-cancer effect of palmitic acid (PA) on EC progression using cellular and xenograft models, combined with integrated transcriptomic and metabolomic analyses to elucidate the molecular pathways through which PA induces ferroptosis and inhibits tumor growth. Methods: The anti-cancer effects of PA were assessed through comprehensive Results: PA significantly reduced the viability, migration, invasion, clonogenic potential, and EMT of EC cells, while inducing cell-cycle arrest and apoptosis. In xenograft models, PA effectively suppressed tumor growth. Mechanistically, transcriptomic and metabolomic analyses, together with changes in ferroptosis-related markers, indicated that PA exerts its anti-cancer effects at least in part through ferroptosis activation. This conclusion was further supported by multiple ferroptosis hallmarks and ferrostatin-1 rescue, which substantially attenuated PA-induced phenotypic and biochemical alterations. Conclusion: PA suppressed EC progression by inducing ferroptosis, providing novel mechanistic insights into PA's anti-cancer properties and underscoring its potential as a therapeutic candidate for EC treatment.

Indexed as

Endometrial cancerFerroptosisMetabolic reprogrammingPalmitic acidTumor progression

Identifiers

PMID41717082
PMCPMC12914859

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.