ArticleCureus2026
Progesterone Enhances the Sensitivity of Ovarian Cancer Cells to Poly (ADP-Ribose) Polymerase (PARP) Inhibitors by Suggesting a Role for Transcription-Replication Conflict-Related Pathways: An In Vitro Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Defining the Role of Progesterone Signaling in High-Grade Serous Ovarian Cancer Using Fallopian Tube Models.Research square · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOvarian cancer is often diagnosed at an advanced stage with peritoneal dissemination and ascites. Despite initial chemosensitivity, most patients eventually relapse. Poly (ADP-ribose) polymerase (PARP) inhibitors have become important maintenance therapies, particularly for tumors with homologous recombination deficiencies. Transcription-replication conflicts (TRCs) are increasingly recognized as a key mechanism related to PARP inhibitor-induced cytotoxicity. Progesterone exerts rapid non-genomic effects via membrane progesterone receptors (mPRs), suppresses topoisomerase I (TOPO-I), and enhances irinotecan cytotoxicity in ovarian cancer cells. We hypothesized that combining progesterone with PARP inhibitors could enhance antitumor effects by modulating TRC-protective pathways.
methodsThe BRCA1/2 wild-type ovarian cancer cell line SHIN-3 (PR-negative and mPR-positive), which is considered resistant to PARP inhibitors, was treated with progesterone (100-400 μM) and three PARP inhibitors (niraparib, olaparib, and AZD2461). Cell viability was assessed using a colorimetric assay to determine IC
resultsProgesterone significantly reduced the IC
conclusionsProgesterone enhances the sensitivity of ovarian cancer cells to PARP inhibitors by downregulating TRC-protective factors via mPR-mediated non-genomic actions. These in vitro findings suggest a potential preclinical rationale for combining progesterone with PARP inhibitors in BRCA-wild-type ovarian cancer; in vivo validation and dosing studies are needed before clinical consideration.
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