Evidence map›Paper›PMID 41717222›Full record

ArticleFrontiers in aging neuroscience2026

SK channel upregulation and sex-specific mechanisms drive spinal motoneuron reduced excitability with age.

Ibrahim Abdul Halim, Kalin R Gerber, Weston B Gelford, Cierra L Ellington, Mohamed H Mousa, Teresa L Garrett, Sherif M Elbasiouny

Abstract read
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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ibrahim Abdul HalimDepartment of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, OH, United States.
Kalin R GerberDepartment of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, OH, United States.
Weston B GelfordDepartment of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, OH, United States.
Cierra L EllingtonDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, College of Science and Mathematics, Wright State University, Dayton, OH, United States.
Mohamed H MousaDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, College of Science and Mathematics, Wright State University, Dayton, OH, United States.
Teresa L GarrettDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, College of Science and Mathematics, Wright State University, Dayton, OH, United States.
Sherif M ElbasiounyDepartment of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, OH, United States.

Funding

Mechanisms Underlying Excitability Regulation of Motoneuron Types in ALSR01NS091836 · NINDS · WRIGHT STATE UNIVERSITY · 2023 to 2025
$1.0M
Excitability Dysfunction Mechanisms Underlying the TDP43-Dependent ALS and FTD PathogenesisR01NS131816 · WRIGHT STATE UNIVERSITY · 2025 to 2025
$734k
Motoneuronal mechanisms underlying age-related muscle weaknessR01AG067758 · OHIO UNIVERSITY ATHENS · 2025 to 2025
$552k
NIA NIH HHS R01 AG067758NINDS NIH HHS R01 NS091836NINDS NIH HHS R01 NS131816
6 · The paper itself

Abstract

Introduction: Mechanisms underlying age-related weakness are not fully understood, with neuronal mechanisms recently gaining attention. Despite studies on excitatory and inhibitory inputs, conflicting findings on Methods: Using electrophysiological and immunohistochemical approaches, we present direct assessment of intrinsic excitability, cell size, and ion channel membrane expression in adult spinal Results: Our findings reveal a decline in intrinsic excitability of spinal Discussion: These findings reveal sex-specific aging mechanisms in motoneurons, explain women's higher frailty risk, and identify novel drug targets to counteract age-related muscle weakness and neuromuscular decline in older adults.

Indexed as

agingintrinsic excitabilitymotoneuron typesSK channelsspinal motoneuronsweakness

Identifiers

PMID41717222
PMCPMC12913407

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.