Evidence map›Paper›PMID 41717281›Full record

ArticleEnvironmental epigenetics2026

Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood.

Sandra India-Aldana, Hachem Saddiki, Luigi Annicchiarico, Alexandra Chirvasuta, Corina Lesseur, Julio Landero, Damaskini Valvi, Alejandra Cantoral, Andrea A Baccarelli, Martha María Téllez-Rojo and 2 more

Abstract read
In one paragraph

Article in Environmental epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sandra India-AldanaDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.ORCID https://orcid.org/0000-0003-3754-6691
Hachem SaddikiDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.
Luigi AnnicchiaricoDepartment of Clinical Sciences and Community Health, Laboratory of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro," University of Milan, Milan, 20122, Italy.
Alexandra ChirvasutaHasso Plattner Institute, Potsdam, 14482, Germany.
Corina LesseurDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.
Julio LanderoDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.
Damaskini ValviDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.ORCID https://orcid.org/0000-0003-4633-229X
Alejandra CantoralHealth Department, Iberoamericana University, Mexico City, 01219, Mexico.ORCID https://orcid.org/0000-0002-1397-8476
Andrea A BaccarelliHarvard T.H. Chan School of Public Health, Boston, MA, 02115, United States.
Martha María Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, 62100, Mexico.
Robert O WrightDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.
Elena ColicinoDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES013744
6 · The paper itself

Abstract

Metal(loid) exposure can exert immunotoxic effects, including changes in white blood cell proportions. The impact from metal exposure mixtures during pregnancy has not been examined in relation to cell-type composition at birth. Our aim was to evaluate the associations between a prenatal metal(loid) exposure mixture and cord blood DNA methylation-derived cell-type composition. We leveraged the PROGRESS birth cohort with measured prenatal immunotoxic metal(loid)s in blood (manganese, lead) and urine (arsenic, cadmium) and DNA methylation-derived cell-type composition from cord blood (

Indexed as

cell proportioncord bloodexposure mixturesheavy metals

Identifiers

PMID41717281
PMCPMC12914215

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.