ArticleMolecular therapy. Nucleic acids2026
An atlas of cGAS-STING signaling in pathophysiological angiogenesis and retinal vascular homeostasis across species.
Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Abnormal angiogenesis is the leading cause of vision loss globally, but current anti-angiogenic treatments are unsatisfactory and incompetent. Thus, novel therapies targeting angiogenesis are urgently needed. Previously, we revealed a positive association between cGAS-STING signaling and angiogenic factors in the mouse model with ischemic retinopathy. However, whether cGAS-STING signaling regulates retinal angiogenesis remained largely unknown. Here, we analyzed single-cell RNA sequencing databases from the epiretinal fibrovascular membranes, developing mouse retinas, and normal adult retinas from
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