ArticleFrontiers in endocrinology2026
Characteristics and outcome of pediatric and adult differentiated thyroid cancer with distant metastases.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Previous studies suggested differences in the histopathological and molecular characteristics and outcome between pediatric and adult differentiated thyroid cancer (DTC). In this study, we focused on the characteristics and outcome of distant metastases (DM) between pediatric and adult patients with DTC. Objectives: To compare DM between pediatric (pDTC) and adult DTC (aDTC). Patients and methods: We studied 35 pDTC (≤ 18 years) and 79 aDTC with DM seen over 20 years. The median age was 16 and 55 years and the F:M ratio was 3.4:1 and 1.7:1, respectively. Total thyroidectomy was performed in 91.4% and 93.7% and lymph node dissection in 94.3% and 64.6% of pediatric and adult patients, respectively. Radioactive iodine (RAI) ablation/therapy was administered to all patients except one. Results: pDM mostly involved a single organ (34/35), predominantly the lungs (32/35), and rarely the bone (2/35) and brain (1/35). By contrast, aDM were frequently multi-organ (45/79) involving lungs (72 patients), bone (50), brain (9), liver (10), kidneys (3), adrenal glands (2), breast (1) and soft tissues (3). Additional therapies (e.g. surgery, RAI) were administered to 28 and 78 pediatric and adult patients, respectively. At the last follow-up, only 1 (2.9%) vs. 6 (7.6%) patients had progressive metastases and 1 (2.9%) vs. 46 (58.2%) patients died due to DTC in pediatric and adult groups, respectively (P<0.0001). Other patients either were in an indeterminate status or had stable non-progressive metastases. Conclusions: pDM mostly involve single organs and have good outcome and rare mortality. aDM are frequently multi-organ, progressive and associated with high mortality of 58% over about 4.5 years.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.