Evidence map›Paper›PMID 41718093›Full record

ReviewNon-coding RNA2026

Mechanisms at the Intersection of lncRNA and m6A Biology.

Samuel J Gonzalez, Edgardo Linares, Allison M Porman Swain, Aaron M Johnson

Abstract readReview
In one paragraph

Review in Non-coding RNA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel J GonzalezDepartment of Biochemistry, Anschutz Medical Campus, Molecular Genetics University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-5372-8068
Edgardo LinaresDepartment of Biochemistry, Anschutz Medical Campus, Molecular Genetics University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0001-5233-0552
Allison M Porman SwainDepartment of Chemistry, United States Air Force Academy, Colorado Springs, CO 80840, USA.ORCID 0000-0001-8107-0366
Aaron M JohnsonDepartment of Biochemistry, Anschutz Medical Campus, Molecular Genetics University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0003-4553-1078

Funding

Training Program in Cancer BiologyT32CA190216 · NCI · UNIVERSITY OF COLORADO DENVER · PI Craig T. Jordan · 2016 to 2026
$3.5M
Air Force Office of Scientific Research (AFOSR) N/ANCI NIH HHS T32 CA190216NIH HHS 1R21CA270573-02NIH HHS 1R35GM144358-04NIH HHS 1T32CA190216-03NIH HHS 1T32GM008730-05
6 · The paper itself

Abstract

This review provides a thorough survey of long noncoding RNAs that bear the RNA modification N6-methyladenosine (m6A) and current work to understand the resulting mechanistic and biological consequences. We give an overview of lncRNA and m6A biology first, describing the writers, erasers, and readers of m6A and their targeting of lncRNAs. Next, we give an in-depth review of the field of nuclear lncRNAs that regulate chromatin and their regulation via m6A. We then describe the growing appreciation of liquid-liquid phase separation properties in lncRNA and m6A biology. Finally, we cover examples of cytoplasmic lncRNAs regulated by m6A. Overall, this review aims to emphasize how epitranscriptomics influences noncoding RNA mechanisms to provide additional layers of regulation, integrated into downstream biological processes.

Indexed as

epitranscriptomicsgene regulationlong noncoding RNAN6-methyladenosine (m6A)

Identifiers

PMID41718093
PMCPMC12922158

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.