ArticleEuropean burn journal2026
Effect of a 6-Week Structured Exercise Intervention on TNF-α During the Chronic Recovery Phase of a Burn Injury Compared to Regular Daily Activities: A Pilot Randomised Cross-Over Trial.
Article in European burn journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBurn injury induces a prolonged inflammatory response that may contribute to long-term metabolic dysfunction. Exercise is known to reduce inflammation in various clinical populations; however, its effect on chronic post-burn inflammation remains unclear. This crossover trial investigated the impact of a 6-week exercise intervention on tumour necrosis factor-alpha (TNF-α) in adults with non-severe burns sustained more than one year prior.
methodsTwenty-one participants were randomised to complete either a 6-week exercise program or a control period first, separated by a 4-week washout. The exercise program comprised three supervised sessions per week of combined resistance and cardiovascular training. Primary (TNF-α) and secondary (muscle strength, cardiovascular fitness) outcomes were assessed pre- and post-intervention.
resultsFifteen participants completed the protocol with high adherence (90.4%). Exercise significantly improved quadriceps strength and cardiovascular fitness, confirming the intervention's safety and efficacy in this cohort. However, TNF-α concentrations were not elevated at baseline and did not significantly change following exercise compared with control (mean difference: +0.5 pg·mL
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