Evidence map›Paper›PMID 41718621›Full record

ArticleThe Journal of physiology2026

The sympathoregulatory region of the mouse rostral brainstem relies on both GABA and glycine to generate inhibitory currents.

Hong Gao, Lucie D Desmoulins, Adrien J R Molinas, Courtney M Dugas, Andrea Zsombok, Andrei V Derbenev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hong GaoDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA.
Lucie D DesmoulinsDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA.
Adrien J R MolinasDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA.
Courtney M DugasDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA.
Andrea ZsombokDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA.ORCID 0000-0002-1412-0041
Andrei V DerbenevDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA.ORCID 0000-0002-2320-7632

Funding

Brain Circuits Involved in the Sympathetic Control of the LiverR01DK122842 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI DERBENEV, ANDREI, ZSOMBOK, ANDREA · 2020 to 2023
$2.4M
Glycinergic inhibition in the ventral brainstemR01DK137224 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Andrei Derbenev, Andrea Zsombok · 2024 to 2026
$1.7M
NIDDK NIH HHS R01 DK122842NIDDK NIH HHS R01 DK137224
6 · The paper itself

Abstract

Presympathetic neurons in the ventrolateral and ventromedial medulla (VLM/VMM) control sympathetic tone, and GABA and glycine were identified as inhibitory neurotransmitters. Although glycinergic inhibition of presympathetic neurons in the VLM/VMM has been shown, the sources of glycinergic inputs and the mechanism of glycine release are ill-defined. Here, we tested whether presympathetic neurons in the VLM/VMM receive glycinergic inputs. Glycine is recycled by glycine transporter 2 (GlyT

Indexed as

Brain Stemgamma-Aminobutyric AcidGlycineAnimalsFemaleGlycine Plasma Membrane Transport ProteinsInhibitory Postsynaptic PotentialsMaleMedulla OblongataMiceMice, Inbred C57BLMice, TransgenicNeuronsgamma-Aminobutyric AcidGlycineGlycine Plasma Membrane Transport ProteinsSlc6a5 protein, mouseautonomic nervous systemelectrophysiologyGABAglycineglycine transporter 2pseudorabies virusRVLMVLM/VMM

Identifiers

PMID41718621
PMCPMC13039250

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.