Evidence map›Paper›PMID 41718726›Full record

Trial reportActa diabetologica2026

Effect of a 1-year supervised exercise intervention on long-term mortality in people with type 2 diabetes.

Stefano Balducci, Jonida Haxhi, Martina Vitale, Lorenza Mattia, Francesco Calvi, Martina Marini, Eleonora Ciocca, Federica Auccello, Andrea Gentile, Lucilla Bollanti and 5 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stefano BalducciDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Jonida Haxhi *Department of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Martina VitaleDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Lorenza MattiaDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Francesco CalviDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Martina MariniDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Eleonora CioccaDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Federica AuccelloDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Andrea GentileDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Lucilla BollantiDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.
Massimo SacchettiDepartment of Human Movement and Sport Sciences, University of Rome 'Foro Italico', Rome, Italy.
Giorgio OrlandoDepartment of Human Movement and Sport Sciences, University of Rome 'Foro Italico', Rome, Italy.
Antonio NicolucciCenter for Applied Biological and Exercise Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK.
Giuseppe PuglieseDepartment of Clinical and Molecular Medicine, La Sapienza" University, University of Rome 'La Sapienza', Via Di Grottarossa, 1035-1039, 00189, Rome, Italy. giuseppe.pugliese@uniroma1.it.ORCID http://orcid.org/0000-0003-1574-0397
Italian Diabetes, Exercise Study (IDES) Investigators

Funding

Bristol-Myers Squibb NALifeScan NAMetabolic Fitness Foundation NANovo Nordisk NATechnogym NA
6 · The paper itself

Abstract

aimsTo assess the effect of a 1-year supervised exercise training program on long-term mortality in people with type 2 diabetes.

methodsThis is a post hoc analysis of the Italian Diabetes and Exercise Study randomized clinical trial, which enrolled 606 physically inactive and sedentary individuals with type 2 diabetes from October 2005 to March 2006. Participants were randomized 1:1 to either an exercise group (EXE) receiving a twice-weekly, progressive, supervised aerobic and resistance exercise training plus a physical activity (PA) counseling or a control group (CON) receiving counseling alone for one year. The vital status of participants was verified on 30 June 2024 by interrogating the Italian Health Card database.

resultsA similar number of EXE and CON participants died over a mean 16.2-year follow-up (88 vs. 95, p = 0.536). Likewise, no between-group differences were detected in death rates (unadjusted, 17.62 [95% confidence interval, 14.30-21.71] vs. 19.59 [16.02-23.96] per 1,000 patient-years, p = 0.483; and age- and sex-adjusted, 16.46 [12.81-21.13] vs. 17.93 [13.92-23.09], p = 0.563). Kaplan-Meier estimates (Log Rank = 0.647, p = 0.421) and mortality risk (unadjusted, hazard ratio, 0.888 [95% confidence interval, 0.664-1.187], p = 0.442; and age- and sex-adjusted, 0.922 [0.689-1.233], p = 0.584). A significant relation with mortality was observed for baseline maximal oxygen uptake (VO

conclusionsIn people with type 2 diabetes, a one-year supervised exercise training program had no significant effect on long-term mortality.

trial registrationisrctn.com; ISRCTN-04252749; URL https://www.isrctn.com/ISRCTN04252749 .

Indexed as

Diabetes Mellitus, Type 2ExerciseExercise TherapyAgedFemaleFollow-Up StudiesHumansItalyMaleMiddle AgedResistance TrainingAll-cause mortalityCounselingPhysical fitnessSupervised exerciseType 2 diabetes

Identifiers

PMID41718726

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.