Evidence map›Paper›PMID 41718919›Full record

ArticleMaternal and child health journal2026

Prenatal and Maternal Contributors to Disease Severity in Congenital Heart Disease.

Masahiro Nishide, Desiree C K Hilton, Gary F Sholler, David S Winlaw, Sally L Dunwoodie, Natasha Nassar, Samantha J Lain, Gillian M Blue

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Article in Maternal and child health journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Masahiro NishideSydney Medical School, The University of Sydney, Sydney, Australia.
Desiree C K HiltonSydney Medical School, The University of Sydney, Sydney, Australia.
Gary F ShollerSydney Medical School, The University of Sydney, Sydney, Australia.
David S WinlawAnn and Robert H. Lurie Children's Hospital of Chicago, Illinois, USA.
Sally L DunwoodieVictor Chang Cardiac Research Institute, Darlinghurst, Sydney, Australia.
Natasha NassarChildren's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Samantha J LainChildren's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Gillian M BlueSydney Medical School, The University of Sydney, Sydney, Australia. gillian.blue@health.nsw.gov.au.ORCID http://orcid.org/0000-0002-1480-9535

Funding

National Health and Medical Research Council 1135886National Health and Medical Research Council 1181325National Health and Medical Research Council 1197940NSW Ministry of Health Cardiovascular Research Capacity Program EMCR05NSW Ministry of Health Career Advancement Grant
6 · The paper itself

Abstract

introductionMost congenital heart disease (CHD) is due to a combination of genetic and environmental factors. Recent findings suggest a polygenic inheritance in more complex CHD, highlighting a role for environmental factors in final disease presentation. Using data linkage, this study investigated the association of prenatal factors and maternal chronic health conditions with CHD severity.

methodPatients from the Kids Heart BioBank (n = 2389) were linked to the NSW Perinatal Data Collection and the NSW Admitted Patient Data Collection containing prenatal and maternal health records. CHD cases were grouped into two categories according to disease severity: (i) complex CHD (comprising patients requiring neonatal intervention, n = 581) and (ii) other CHD (comprising patients requiring intervention after the neonatal period, n = 1808). Prenatal factors and chronic health conditions were coded using ICD-10-AM classification and compared across severity groups and healthy controls (n = 58,624).

resultsAnalyses identified a significant increase in preexisting diabetes mellitus (p = 0.003), and urinary tract infections (p = 0.01) in mothers of infants with complex CHD compared to other CHD. Conversely, circulatory system disorders and preeclampsia/gestational hypertension were reduced in mothers of infants with complex CHD compared to other CHD (p = 0.01 and p = 0.06, respectively). These risks remained after adjusting for confounding factors including socioeconomic status, smoking, age at pregnancy, gestational age and year of birth.

conclusionThese findings suggest an important role for prenatal factors and maternal chronic health conditions in CHD severity, in line with previous reports supporting polygenic inheritance in complex disease with contributions from environmental 'stressors' in the final disease presentation. Importantly, these findings hold promise for future primary prevention for complex CHD through therapeutic treatments of potentially modifiable factors in pregnancy.

Indexed as

Heart Defects, CongenitalMothersPregnancy ComplicationsSeverity of Illness IndexAdultFemaleHumansInfant, NewbornNew South WalesPregnancyRisk FactorsCongenital heart diseaseData linkage approachesDisease severityPrenatal and maternal factors

Identifiers

PMID41718919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.