Evidence map›Paper›PMID 41718921›Full record

ReviewInflammopharmacology2026

Neuroinflammatory control of metabolism in huntington's disease: central role of P2 × 7 receptor mediated redox lipid/epigenetic crosstalk.

Vandana Bhatia, Gayatri Bisht, Tanika Thakur, Harshita Thakur, M S Ashawat

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vandana BhatiaDepartment of Pharmacology, Distt. Kangra, Laureate Institute of Pharmacy, Kathog, Kangra, Himachal Pradesh, 176031, India. vandana.bhatia40@gmail.com.ORCID http://orcid.org/0000-0002-1614-7192
Gayatri BishtDepartment of Pharmacology, Distt. Kangra, Laureate Institute of Pharmacy, Kathog, Kangra, Himachal Pradesh, 176031, India.
Tanika ThakurDepartment of Pharmacology, Distt. Kangra, Laureate Institute of Pharmacy, Kathog, Kangra, Himachal Pradesh, 176031, India.
Harshita ThakurDepartment of Pharmacology, Distt. Kangra, Laureate Institute of Pharmacy, Kathog, Kangra, Himachal Pradesh, 176031, India.
M S AshawatDepartment of Pharmaceutics, Distt. Kangra, Laureate Institute of Pharmacy, Kathog,Kangra, Himachal Pradesh, 176031, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder in which neuroinflammation, oxidative stress, and mitochondrial dysfunction are increasingly recognized as important contributors to neuronal vulnerability. Recent evidence indicates that the ATP-gated P2X7 receptor (P2X7R) may participate in coordinating several of these pathological processes. Under conditions of cellular stress, elevated extracellular ATP can promote sustained activation of P2X7R, leading to Ca

Indexed as

Epigenesis, GeneticHuntington DiseaseNeuroinflammatory DiseasesReceptors, Purinergic P2X7AnimalsHumansLipid PeroxidationOxidation-ReductionOxidative StressReactive Oxygen SpeciesReactive Oxygen SpeciesReceptors, Purinergic P2X7Epigenetic dysregulationHuntington’s diseaseLipid peroxidationNeuroinflammationOxidative stressP2X7 receptor

Identifiers

PMID41718921

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.