ArticleEBioMedicine2026
High-dimensional single-cell analyses reveal neutrophil heterogeneity in guttate psoriasis.
Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Antigen-presenting neutrophils link streptococcal infection to adaptive immune activation in guttate psoriasis.EBioMedicine · 2026Article
- NasalJournal of inflammation research · 2026Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuttate psoriasis (GP) is associated with streptococcal throat infection. Neutrophils are the first immune cells to respond to Group A Streptococcal (GAS) infection, but detailed analysis of their contribution to GP pathogenesis is lacking. The study primarily focuses on phenotyping the neutrophils located at the site of inflammation in GP skin and understanding their specific contribution to the pathogenesis of the disease.
methodsHere, we performed a comprehensive immunophenotypic and transcriptomic analysis of neutrophils from blood and inflamed GP skin using high-dimensional single-cell protein and RNA analyses. Ex vivo stimulation of neutrophils and co-culture with CD4
findingsWe uncovered high diversity of human neutrophils in GP, with enrichment of an immature subset in GP skin that exhibited antigen processing and presentation signature. A similar subset in healthy controls was observed only upon ex vivo stimulation of neutrophils with GAS bacteria. Additionally, the GAS-induced neutrophil subset was found to induce CD4
interpretationOur study depicts the landscape of neutrophils in GP skin and highlights HLA-DR
fundingThis work was supported by HudFonden, Psoriasisfonden, Gösta A Karlssons 60-års fond, Magnus Bergvall stiftelse, Åke Wibergs stiftelse, and Karolinska Institute. AP was supported by HudFonden. PA was partially supported by Karolinska Institute's doctoral funding (KID). LPM was supported by grants from Svenska Sällskapet för Medicinsk Forskning (SSMF) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID). UN was supported by grants from the Swedish Research Council. JL was supported by Region Stockholm (clinical postdoctoral appointment). ML was supported by the Swedish Childhood Cancer research fund and the Karolinska Institute. Part of the data handling was enabled by resources at project number SNIC-2021/22-49 provided by the Swedish National Infrastructure for Computing (SNIC), partially funded by the Swedish Research Council through grant agreement no. 2018-05973.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.