Evidence map›Paper›PMID 41720488›Full record

Trial reportEuropean journal of sport science2026

The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-Blind and Placebo-Controlled Crossover Trial.

Rebecca A Neal, Jo Corbett, Joseph T Costello, Zoe L Saynor, Clare M Eglin, Maria Perissiou, Michael Cummings, Hermione Price, Stephen J Bailey, S Sendhil Velan and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of sport science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rebecca A NealDepartment of Rehabilitation and Sport Sciences, Bournemouth University, Poole, UK.
Jo CorbettExtreme Environments Laboratory, School of Psychology, Sport & Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.ORCID https://orcid.org/0000-0002-6552-6471
Joseph T CostelloExtreme Environments Laboratory, School of Psychology, Sport & Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Zoe L SaynorSchool of Health Sciences, Faculty of Environmental and Life Sciences, Southampton University, Southampton, UK.
Clare M EglinExtreme Environments Laboratory, School of Psychology, Sport & Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Maria PerissiouClinical Health and Rehabilitation Team, School of Psychology, Sport & Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Michael CummingsDiabetes and Endocrinology Department, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
Hermione PriceResearch and Development Tom Rudd Unit, Moorgreen Hospital, Southern Health NHS Foundation Trust, Southampton, UK.ORCID https://orcid.org/0000-0003-3388-0975
Stephen J BaileyNational Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
S Sendhil VelanHuman Magnetic Resonance Centre, Institute of Applied Life Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
Suresh Anand SadananthanInstitute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.ORCID https://orcid.org/0000-0001-5938-1694
John TotmanFatima College of Health Sciences, Abu Dhabi, UAE.
Janet Rennell-SmythPateint and Public Involvement Member, University of Portsmouth, Portsmouth, UK.
Anthony I ShepherdExtreme Environments Laboratory, School of Psychology, Sport & Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.ORCID https://orcid.org/0000-0001-6392-7944

Funding

Bournemouth University
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a metabolically active brown adipose phenotype in rats may offer adjunct treatment in people with T2DM. To investigate whether inorganic nitrate supplementation from beetroot juice (BJ) alters brown adipose tissue (BAT) fat fraction and activation in humans. Thirteen older adults with T2DM (glycated haemoglobin [HbA1c]: 58 ± 13 mmol·mol

Indexed as

Adipose Tissue, BrownDiabetes Mellitus, Type 2NitratesAgedBeta vulgarisCross-Over StudiesDietary SupplementsDouble-Blind MethodFemaleFruit and Vegetable JuicesHumansMagnetic Resonance ImagingMaleNitritesThermogenesisThermographyNitratesNitritesbeetrootbrown adipose tissueinfra‐red thermographyMRIproton density fat fraction

Identifiers

PMID41720488
PMCPMC12928037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.