ArticleNature communications2026
Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex.
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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
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Who cites it
6 citing papers in PubMed.
- Beyond lactation: Central oxytocin in maternal mental health and disease.Neuroscience and biobehavioral reviews · 2026Review
- Maternal experience alters brain-wide representation of infant cries.bioRxiv : the preprint server for biology · 2026Article
- Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex.Neurobiology of stress · 2026Article
- Comparative gene editing reduces dopamine receptor levels across rodent species.bioRxiv : the preprint server for biology · 2025Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
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Authors and funding
36 authors.
Stephanie Schimmer *Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Alan Kania *Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-3823-6196
Arthur Lefevre *Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0003-2847-0859
Konstantinos AfordakosDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0009-0007-4249-559X
Kai-Yi WangCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Julia LebedevaDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-3874-9549
Andrei RozovInstitute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-4932-4095
Androniki RaftogianniDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-1850-8916
Rishika TiwariSagol Department of Neurobiology, the Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel.
Shai NetserSagol Department of Neurobiology, the Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel.ORCID 0000-0003-4176-1124
Ana ZovkoDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Huma ShaheenDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Jonas SchimmerDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Ryan PatwellDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-1885-1634
Clémence DenisCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Valentin GrelotCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Hugues PetitjeanDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Lan GengState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing, China.
Dimitri HefterDepartment of Animal Models in Psychiatry, Central Institute of Mental Health, Clinic Psychiatry and Psychotherapy, Mannheim, Germany.
Arjen BoenderCenter for Translational Social Neuroscience, Division of Behavioral Neuroscience and Psychiatric Disorders, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6018-3588
Yuval PodpecanInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Franziska SchommerInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0009-0001-4966-3986
Tim SchubertInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0009-0003-1696-4402
Anna SanetraDepartment of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Krakow, Krakow, Poland.ORCID 0000-0002-3070-4688
Aleksandra TrenkDepartment of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Krakow, Krakow, Poland.ORCID 0000-0002-5888-3550
Anna GugulaDepartment of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Krakow, Krakow, Poland.ORCID 0000-0003-0045-9025
René HurlemannDepartment of Psychiatry, School of Medicine & Health Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Shlomo WagnerSagol Department of Neurobiology, the Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel.ORCID 0000-0002-7618-0752
Yulong LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing, China.ORCID 0000-0002-9166-9919
Ferdinand AlthammerInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Anna BlasiakDepartment of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Krakow, Krakow, Poland.ORCID 0000-0002-4017-2988
Sarah MelzerDepartment of Neuronal Cell Biology (Center for Brain Research), Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6028-9764
Hannah MonyerDepartment of Clinical Neurobiology, Medical Faculty of Heidelberg University and DKFZ, Heidelberg, Germany.ORCID 0000-0002-9332-5749
Alexandre CharletCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.ORCID 0000-0003-4837-3706
Marina EliavaDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. marina.eliava@zi-mannheim.de.
Valery GrinevichDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. valery.grinevich@zi-mannheim.de.ORCID 0000-0002-6337-8866
Funding
CNRS International Research ProjectDeutsche Forschungsgemeinschaft (German Research Foundation) 533293533German-Israeli Project cooperation (DIP)National Science Centre, PolandSynergy European Research Council (ERC)V.G., S.F.B. Consortium
Abstract
The hypothalamic neuropeptide oxytocin is best known for its prosocial behavioral effects. However, the precise anatomical and cellular targets for oxytocin in the cortex during social behavior remain elusive. Here we show that oxytocin neurons project directly to the medial prefrontal cortex where evoked axonal oxytocin release facilitates social behaviors in adult female rats. In conjunction, we report that local oxytocin receptor-expressing (OTR
Indexed as
InterneuronsOxytocinPrefrontal CortexSocial BehaviorAnimalsFemaleRatsReceptors, OxytocinOxytocinReceptors, Oxytocin
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What Socratic holds
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.