Evidence map›Paper›PMID 41720971›Full record

ReviewNature cell biology2026

Cellular mechanisms of brain lipid metabolism in health and disease.

Francesco Petrelli, Carlotta Gilardi, Carla Marie Igelbüscher, Diana Panfilova, Alicia Rey, Rosa Chiara Paolicelli, Marlen Knobloch

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco PetrelliDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. francesco.petrelli.1@unil.ch.ORCID http://orcid.org/0000-0003-0696-7039
Carlotta Gilardi *Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6373-3445
Carla Marie Igelbüscher *Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0009-0009-5147-0866
Diana Panfilova *Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1166-5572
Alicia ReyDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0009-0004-3342-4472
Rosa Chiara PaolicelliDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6851-0849
Marlen KnoblochDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. marlen.knobloch@unil.ch.ORCID http://orcid.org/0000-0002-7490-0285

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid metabolism has recently regained considerable attention in neuroscience, as disturbances in lipid metabolic pathways have been linked to neurodevelopmental and neurodegenerative diseases. Here we examine brain lipid metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer. We cover the recent literature showing how these processes are important during brain development and how they occur in diverse brain cell types, including astrocytes, oligodendrocytes, neural stem and progenitor cells, microglia and neurons in the adult brain. We further discuss the consequences of disrupted lipid metabolism and highlight emerging insights into neuron-glia lipid exchange, as well as the importance of lipid droplets for brain health and disease.

Indexed as

BrainLipid MetabolismNeurodegenerative DiseasesAnimalsAstrocytesHumansMicrogliaNeurogliaNeurons

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.