ArticleBMC research notes2026
Analysis of drug-induced adverse reactions affecting appetite and taste using the Japanese Adverse Drug Event Report Database.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivePharmacotherapy is a potential risk factor for undernutrition; however, the association between individual drugs and nutrition-related adverse reactions remains unknown. We aimed to explore drugs affecting appetite and taste using the Japanese Adverse Drug Event Report (JADER) database.
methodsJADER reports (April 2004-January 2025) were analyzed for drug safety signals across seven Preferred Terms (PTs): "Appetite disorder," "Decreased appetite," "Abnormal loss of weight," "Ageusia," "Dysgeusia," "Hypogeusia," and "Taste disorder." Signal detected drugs were classified by therapeutic category, and their package insert information was reviewed.
resultsAmong 20,638 nutrition-related adverse reaction reports, signals were detected for 54, 14, 24, and 13 drugs for "Decreased appetite," "Ageusia," "Dysgeusia," and "Taste disorder", respectively. No signals were detected for the other three PTs. Regarding therapeutic category, other hormone preparations were common for "Decreased appetite," while anti-viral agents were common for "Dysgeusia" and "Taste disorder." Of these, five and 15 drugs lacked descriptions in the package inserts regarding decreased appetite and taste-related adverse reactions, respectively.
conclusionsThis study clarified drugs that may affect appetite and taste, providing a focused list for early detection. These findings may enhance pharmacovigilance practices and inform clinical approaches for managing drug-induced nutritional concerns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.