Evidence map›Paper›PMID 41721487›Full record

ArticleThe Journal of physiology2026

Ascl3

Hitoshi Uchida, Eri O Maruyama, Takahiro Takano, Marit H Aure, Melissa F Glasner, Zamira Guerra Soares, Roberta C Faustoferri, V Kaye Thomas, Helen P Makarenkova, David I Yule and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Hitoshi UchidaCenter for Oral Biology, University of Rochester School of Medicine, Rochester, New York, USA.
Eri O MaruyamaCenter for Oral Biology, University of Rochester School of Medicine, Rochester, New York, USA.
Takahiro TakanoDepartment of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York, USA.
Marit H AureCenter for Oral Biology, University of Rochester School of Medicine, Rochester, New York, USA.
Melissa F GlasnerCenter for Oral Biology, University of Rochester School of Medicine, Rochester, New York, USA.
Zamira Guerra SoaresDepartment of Biomedical Genetics, University of Rochester School of Medicine, Rochester, New York, USA.
Roberta C FaustoferriCenter for Oral Biology, University of Rochester School of Medicine, Rochester, New York, USA.
V Kaye ThomasCenter for Advanced Light Microscopy, University of Rochester School of Medicine, Rochester, New York, USA.
Helen P MakarenkovaDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.
David I YuleDepartment of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York, USA.
Catherine E OvittCenter for Oral Biology, University of Rochester School of Medicine, Rochester, New York, USA.

Funding

[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR01DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2002 to 2026
$9.9M
An experimental/computational approach for understanding salivary fluid secretionR01DE019245 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2008 to 2026
$9.7M
Salivary gland ionocyte organization and function during homeostasis, repair, and diseaseR01DE031044 · NIDCR · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2021 to 2025
$3.0M
STED3X Super Resolution Microscope for The University of Rochester and Western NY research communityS10OD023440 · OD · UNIVERSITY OF ROCHESTER · PI YULE, DAVID I · 2018 to 2018
$600k
Single chemosensory cells in the salivary gland.R21DE026861 · NIDCR · UNIVERSITY OF ROCHESTER · PI OVITT, CATHERINE · 2018 to 2019
$438k
NIDCR NIH HHS R01 DE014756NIDCR NIH HHS R01 DE019245NIDCR NIH HHS R01 DE031044NIDCR NIH HHS R21 DE026861NIH HHS S10 OD023440
6 · The paper itself

Abstract

Ionocytes are distinct epithelial sensory cells scattered throughout the ductal system of the salivary glands. These cells are distinguished by their unusual morphology, as well as by a specific transcriptomic signature that includes the expression of the forkhead boxI1 (Foxi1) and achaete scute-like 3 (Ascl3) transcription factors. Currently little is known about the biology or function of ionocytes in the salivary glands. To facilitate the characterization of these cells, we produced an inducible Cre mouse allele driven by the Ascl3 promoter. This strain was crossed with a reporter to fluorescently label Ascl3

Indexed as

Basic Helix-Loop-Helix ProteinsCalcium SignalingSalivaSalivary DuctsSalivary GlandsSensory Receptor CellsAnimalsFemaleMiceBasic Helix-Loop-Helix ProteinsBhlha15 protein, mouseachaete scute‐like 3 (Ascl3)Ca2+ signallingduct cellsforkhead boxI1 (Foxi1)ionocytessalivasalivary glands

Identifiers

PMID41721487
PMCPMC13374334

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.