Evidence mapPaperPMID 41721545Full record

ReviewCardiovascular research2026

Anticoagulants beyond coagulation: a narrative review of cardiovascular effects.

Annisa Aarts, Hugo Ten Cate, Arina J Ten Cate-Hoek

Abstract readReview
In one paragraph

Review in Cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Annisa AartsThrombosis Expertise Center, Heart+Vascular Center, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.ORCID 0009-0002-6829-1767
Hugo Ten CateThrombosis Expertise Center, Heart+Vascular Center, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.ORCID 0000-0001-7796-4463
Arina J Ten Cate-HoekThrombosis Expertise Center, Heart+Vascular Center, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.ORCID 0000-0002-9900-6212

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anticoagulants are widely used to prevent and treat thrombotic disorders, and continuous advances have refined their efficacy and safety. Beyond their established anticoagulant function, growing evidence indicates that some agents exert additional cardiovascular effects through pleiotropic mechanisms. In this narrative review, we examine both the intended and potential unintended effects of anticoagulants, with particular attention to their actions beyond coagulation. We discuss their influence on vascular pathology and cardiac function, highlighting distinctions between different anticoagulant classes. A deeper understanding of these pleiotropic effects may help guide future research, improve long-term outcomes, and support more targeted therapeutic strategies for patients most likely to benefit.

Indexed as

AnticoagulantsBlood CoagulationCardiovascular DiseasesCardiovascular SystemAnimalsHumansRisk FactorsAnticoagulantsAnticoagulantsDirect oral anticoagulantsHeparinPleiotropyVitamin K antagonists

Identifiers

PMID41721545
PMCPMC13020544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.