Evidence map›Paper›PMID 41722047›Full record

ArticleCell reports2026

GPR75 in glutamatergic neurons regulates body weight.

Steven C Wyler, Surbhi Gahlot, Lara Bideyan, Kyle Brown, Jennifer K Schiavo, Marco Galvan, Shreya Thomas, Arely Tinajero, Adan Khan, Warda Merchant and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Steven C WylerCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Surbhi GahlotCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Lara BideyanCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Kyle BrownRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Jennifer K SchiavoRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Marco GalvanCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Shreya ThomasCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Arely TinajeroCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Adan KhanCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Warda MerchantCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Laurent GautronCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Young-Jai YouCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Jason W MastaitisRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Judith Y AltarejosRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Teppei FujikawaCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Joel K ElmquistCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: joel.elmquist@utsouthwestern.edu.

Funding

UT Southwestern NORCP30DK127984 · UT SOUTHWESTERN MEDICAL CENTER · 2025 to 2025
$1.2M
SF1 neurons and sympathetic regulation of glucose homeostasisR01DK100659 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · 2022 to 2025
$952k
NIDDK NIH HHS P01 DK119130NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK088423NIDDK NIH HHS R01 DK100659
6 · The paper itself

Abstract

The G-protein-coupled receptor 75 (GPR75) emerged as a promising therapeutic target for treating diet-induced obesity (DIO). Loss-of-function mutations of GPR75 in humans are associated with reduced body mass index (BMI). Also, Gpr75-deficient mice are protected from DIO. Here, we generated genetically modified mice that enable us to selectively delete or reactivate Gpr75 in a Cre-dependent manner. Loss of Gpr75 in vGlut2+ glutamatergic neurons (Gpr75

Indexed as

Body WeightGlutamic AcidNeuronsReceptors, G-Protein-CoupledAnimalsDiet, High-FatEatingEnergy MetabolismGABAergic NeuronsMaleMiceMice, Inbred C57BLMice, KnockoutObesityVesicular Glutamate Transport Protein 2Glutamic AcidReceptors, G-Protein-CoupledVesicular Glutamate Transport Protein 2body weightCP: metabolismCP: neurosciencefood intakeGABAergicglutamatergic neuronsGpr75high fat dietmetabolicobesity

Identifiers

PMID41722047
PMCPMC13085398

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.