Evidence map›Paper›PMID 41722228›Full record

SynthesisPoultry science2026

Emulsifiers in poultry nutrition-molecular mechanism of lipid metabolism and energy utilization: A meta-analysis and KEGG mapping.

Danung Nur Adli, Sugiharto Sugiharto, Tri Ujilestari, Agung Irawan, Amirul Faiz Mohd Azmi, Fatim Illaningtyas, Dimar Sari Wahyuni, Novia Qomariyah, Pradita Iustitia Sitaresmi, Rantan Krisnan and 4 more

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Danung Nur AdliSmart Livestock Industry Study Programme, Department of Feed and Animal Nutrition, Faculty of Animal Science and Technology, Universitas Brawijaya, Malang 65145, Indonesia.
Sugiharto SugihartoDepartment of Animal Science, Faculty of Animal and Agricultural Sciences, Universitas Diponegoro, Semarang 50275, Indonesia. Electronic address: sugiharto@lecturer.undip.ac.id.
Tri UjilestariResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Agung IrawanVocational School, Universitas Sebelas Maret, Surakarta 57126, Indonesia.
Amirul Faiz Mohd AzmiDepartment of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Kota Bharu 16100, Malaysia.
Fatim IllaningtyasResearch Center for Sustainable Production Systems and Life Cycle Assessment, National Research and Innovation Agency (BRIN), South Tangerang 15314, Indonesia.
Dimar Sari WahyuniResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Novia QomariyahResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Pradita Iustitia SitaresmiResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Rantan KrisnanResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Riris Delima PurbaResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Procula Rudlof MatitaputtyResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Mochamad Dzaky AlifianResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia.
Mohammad Miftakhus SholikinResearch Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16915, Indonesia. Electronic address: mohammad.miftakhus.sholikin@brin.go.id.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The feed energy derived from fat remains relatively low because young poultry have limited fat digestibility and inefficient lipid metabolism. This study aimed to evaluate the effectiveness of emulsifiers in regulating lipid metabolism and increasing lipase activity in poultry. A quantitative review of 57 studies (2015-2025) revealed that emulsifier supplementation significantly upregulated genes associated with lipogenesis, including diacylglycerol O-acyltransferase 2 (DGAT2), and increased lipolysis through the upregulation of perilipin 1 (PLN1). It also increased the activities of lipoprotein lipase and total lipase. Kyoto Encyclopaedia of Genes and Genomes (KEGG) mapping also suggested that fatty acid biosynthesis (gga00061), β-oxidation (gga00071), the PPAR signalling pathway (gga03320), cholesterol metabolism (hsa04979), and the regulation of lipolysis (gga04923) in adipocyte regulation pathways were synergistically activated. Taken together, these pathways suggest that emulsifiers improve lipid turnover, oxidative metabolism and lipoprotein formation in broiler chickens. In summary, emulsifiers modulate lipid metabolism at the molecular level, which offers mechanistic support for improving energy utilization and may also aid in developing precision nutrition strategies in poultry.

Indexed as

ChickensEmulsifying AgentsEnergy MetabolismLipid MetabolismAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsDietDietary SupplementsEmulsifying AgentsEmulsifierFatty acid oxidationLipogenesisLipoprotein lipasePrecision nutrition

Identifiers

PMID41722228
PMCPMC12934313

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.