Evidence map›Paper›PMID 41723152›Full record

ArticleNature communications2026

Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms.

Lulu Shi, Haibin He, Junpeng Li, Kai Gai, Wenjian Li, Yu Zhao, Huijun Yuan, Yang Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lulu Shi *Department of Otolaryngology-Head and Neck Surgery & Institute of Rare Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0001-5762-770X
Haibin He *Department of Otolaryngology-Head and Neck Surgery & Institute of Rare Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Junpeng LiDepartment of Otolaryngology-Head and Neck Surgery & Institute of Rare Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Kai GaiDepartment of Otolaryngology-Head and Neck Surgery & Institute of Rare Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Wenjian LiDepartment of Otolaryngology-Head and Neck Surgery & Institute of Rare Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yu ZhaoDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huijun YuanDepartment of Otolaryngology-Head and Neck Surgery & Institute of Rare Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. yuanhj301@163.com.
Yang WuDepartment of Otolaryngology-Head and Neck Surgery & Institute of Rare Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. yang.wu@wchscu.edu.cn.ORCID http://orcid.org/0000-0002-0128-7280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related hearing loss is a prevalent and growing public health issue among the elderly. Here, we perform a multi-ancestry genome-wide association study comprising 456,613 cases and 1,053,834 controls, identifying 140 independent loci associated with age-related hearing loss, including 44 novel signals. We further fine-map 9 likely causal missense variants for age-related hearing loss and provide evidence of purifying selection for age-related hearing loss-associated variants. Notably, genetic risk for age-related hearing loss is strongly correlated with behavior traits such as neuroticism score and irritability. Integration of molecular phenotypes identifies 22 genes and 85 DNA methylation sites significantly associated with age-related hearing loss. Moreover, analyses incorporating spatial and single-cell transcriptomic identify the inner ear as a crucial site of age-related hearing loss, emphasizing the importance of hair cells, supporting cells, basal and root cells of the stria vascularis to its pathogenesis. Our study provides genetic and cellular insights into age-related hearing loss and advance our understanding of its genetics architecture.

Indexed as

AgingGenome-Wide Association StudyHearing LossPresbycusisDNA MethylationEar, InnerGenetic Predisposition to DiseaseHumansPolymorphism, Single Nucleotide

Identifiers

PMID41723152
PMCPMC13172361

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.