ArticleCommunications engineering2026
Safe focused ultrasound-mediated blood-brain barrier opening is driven primarily by transient reorganization of tight junctions.
Article in Communications engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- A new in silico model to precisely design focused ultrasound brain therapies.Medical physics · 2026Article
- Focused ultrasound for cellular mechanoactivation and nanomedicine delivery in cancer.Biomedical microdevices · 2026Review
- Review
- Small Particles, Big Impact: Inorganic Nanotechnology for Glioblastoma.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Focused ultrasound (FUS) with microbubbles opens the blood-brain barrier (BBB) for targeted drug delivery into the brain. How brain endothelial cells (BECs) respond to low acoustic pressures known to open the BBB transiently, or high pressures that cause brain damage, is incompletely characterized. Here, we apply FUS at low (450 kPa) and high (750 kPa) pressures in mice where BBB tight junctions are labeled with eGFP to characterize their abnormalities. Arteriole and capillary BECs respond to low pressure by a transient BBB tight junction reorganization and opening. In contrast, high pressure induces tight junction obliteration and persistent BBB opening in BECs even after 72 hours, associated with microglial activation. Transcriptomic analyses of BECs show that high pressure upregulates genes related to the stress response and cell junction disassembly, whereas low pressure upregulates intracellular repair genes. Thus, transient reorganization and repair of tight junctions mediate safe BBB opening for therapeutic delivery.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.