Chronicity moderates the impact of severity on central executive-default mode network functional interactions in depression.

Tamires Zanao, Piergiorgio Salvan, Lais B Razza, Pedro Henrique Rodrigues da Silva, Andre R Brunoni, Jacinta O'Shea

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tamires ZanaoDepartment of Psychiatry, University of São Paulo Medical School, Universidade de São Paulo (USP), São Paulo, Brazil. tzanao@gmail.com.ORCID http://orcid.org/0000-0001-7868-4332

Piergiorgio SalvanOxford University Centre for Integrative Neuroimaging (OxCIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

Lais B RazzaGhent Experimental Psychiatry (GHEP) Lab, Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Ghent, Belgium.

Pedro Henrique Rodrigues da SilvaDepartment of Psychiatry, University of São Paulo Medical School, Universidade de São Paulo (USP), São Paulo, Brazil.

Andre R BrunoniDepartment of Psychiatry, University of São Paulo Medical School, Universidade de São Paulo (USP), São Paulo, Brazil.

Jacinta O'SheaOxford University Centre for Integrative Neuroimaging (OxCIN), Oxford Centre for Human Brain Activity (OHBA), Warneford Hospital, University of Oxford, Oxford, UK. jacinta.oshea@psych.ox.ac.uk.ORCID http://orcid.org/0000-0002-6007-0698

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/20911-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/03235-2 and 2022/09688-4Fundação de Amparo à Pesquisa do Estado de São Paulo 22/03266-0 and 23/13893-5National Institute for Health and Care Research NIHR203316Royal Society and the Wellcome Trust 215451/Z/19/ZWellcome Trust 203139/Z/16/Z and 203139/A/16/Z

6 · The paper itself

Abstract

Neuroimaging has revealed that major depression is underpinned by dysfunctional brain networks, with symptom variability stemming from altered interactions within and between brain regions. While the effect of depression severity is well-studied, the effect of depression duration (chronicity) is relatively neglected, despite its clinical significance. This study examined how severity, chronicity, and their interaction affect brain network connectivity and grey matter volume. Forty-six patients (31 females, mean age 40.5) were assessed using whole-brain network modeling and voxel-based morphometry (VBM). Severity was measured via the Hamilton Depression Rating Scale, and chronicity was defined as an episode lasting over 24 months. The key finding was that chronicity moderated the impact of severity on functional connectivity between the Central Executive Network (CEN) and the precuneus (part of the Default Mode Network, DMN). Chronic versus non-chronic patients showed opposite patterns. Non-chronic patients showed stronger CEN-Default Mode Precuneus connectivity at low severity and weaker at high severity; chronic patients showed the reverse. This study reveals a novel impact of chronicity on CEN-DMN interactions, a neglected moderator of brain-symptom severity correlations in depression.

Indexed as

BrainDefault Mode NetworkDepressionMajor Depressive DisorderNerve NetAdultBrain MappingChronic DiseaseFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedSeverity of Illness IndexBrain network interactionsChronicityDepressionMood disorderResting-state functional connectivitySeverity

Identifiers

PMID41723265

DOI10.1038/s41598-026-40364-2

PMCPMC13022299

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.