Evidence map›Paper›PMID 41723313›Full record

ArticleIn vitro cellular & developmental biology. Animal2026

Establishment and characterization of a cell line (OS-MM) originating from a human malignant melanoma of the oral mucosa.

Tomoaki Shintani, Atsuko Hamada, Sachiko Yamasaki, Yukari Jono, Koichi Koizumi, Ryouji Tani, Akihiko Sakamoto, Yasusei Kudo, Mikihito Kajiya, Souichi Yanamoto and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tomoaki Shintani *Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, 734-8553, Japan. tshintan@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0002-0789-3273
Atsuko Hamada *Department of Oral Oncology, Graduate School of Biomedical, and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
Sachiko YamasakiDepartment of Oral Oncology, Graduate School of Biomedical, and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
Yukari JonoSchool of Medical Sciences, University of East Asia, Shimonoseki, 751-8503, Japan.
Koichi KoizumiDepartment of Oral Oncology, Graduate School of Biomedical, and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
Ryouji TaniOral Maxillofacial Surgery, Chugoku Rosai Hospital, Kure, 737-0193, Japan.
Akihiko SakamotoOral Maxillofacial Surgery, Mazda Hospital, Hiroshima, 735-8585, Japan.
Yasusei KudoDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8504, Japan.
Mikihito KajiyaCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.
Souichi YanamotoDepartment of Oral Oncology, Graduate School of Biomedical, and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
Tetsuji OkamotoDepartment of Oral Oncology, Graduate School of Biomedical, and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.

Funding

Japan Society for the Promotion of Science 19K11723Japan Society for the Promotion of Science 23K24546Japan Society for the Promotion of Science 25K13168
6 · The paper itself

Abstract

The prognosis for patients diagnosed with oral mucosal melanoma is poor, and the etiology of this disease remains to be elucidated. The underlying reason for this is that no malignant melanoma (MM) cell line derived from oral mucosal tissue has been successfully established to date. The establishment of a human MM cell line designated OS-MM from a tissue sample of a patient diagnosed with palatal mucosal melanoma was undertaken. For a period exceeding three decades, tumor cells have undergone uninterrupted proliferation, exhibiting a spindle-like morphology. Chromosomes exhibit a low-triploid pattern with an observed mode of 47. Heterotransplantation of the cells into SCID mice has resulted in the formation of tumor masses. The cells expressed vascular endothelial growth factor (VEGF) and its receptors. The addition of exogenous recombinant VEGF

Indexed as

MelanomaMouth MucosaMouth NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationChromograninsGTP-Binding Protein alpha Subunits, GsHumansMiceMice, SCIDMutationProto-Oncogene Proteins B-rafVascular Endothelial Growth Factor AChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsProto-Oncogene Proteins B-rafVascular Endothelial Growth Factor AAngiogenesisCell lineMalignant melanomaMolecular geneticsOral mucosal melanomaVascular endothelial growth factor (VEGF)VEGF receptor (VEGFR)

Identifiers

PMID41723313
PMCPMC13246917

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.