Evidence map›Paper›PMID 41723324›Full record

ReviewJournal of assisted reproduction and genetics2026

The molecular puzzle of recurrent implantation failure: integrating genetic, epigenetic, and immune mechanisms for precision reproductive medicine.

Qamar Abuhassan, Ghaleb Oriquat, Soumya V Menon, Kabita Chanania, L Inbathamizh, Gunjan Mukherjee, Aashna Sinha, Sayfiddin Baymakov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qamar AbuhassanDepartment of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy,, University of Jordan, Amman, Amman, Jordan.
Ghaleb OriquatFaculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan. goreqat@ammanu.edu.jo.
Soumya V MenonDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, India.
Kabita ChananiaDepartment of Obstetrics & Gynaecology, IMS and SUM Hospital, Siksha O Anusandhan, Bhubaneswar, Odisha, India.
L InbathamizhDepartment of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India.
Gunjan MukherjeeUniversity Institute of Biotechnology, Chandigarh University, Mohali, India.
Aashna SinhaSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, India.
Sayfiddin BaymakovDepartment of surgical diseases N:3, Tashkent State Medical Academy, Tashkent, Uzbekistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent implantation failure (RIF) is a frustrating condition for the majority of infertile couples, occurring when pregnancy does not happen after several embryo transfers through assisted reproductive technologies (ART). ART has progressed over the last few years, but RIF continues for many patients, and the real reason remains unknown in most cases. RIF is a multifactorial condition influenced by both genetic and epigenetic mechanisms. Genetic contributions to RIF can be broadly classified into embryo-related factors (such as chromosomal aneuploidies and single-gene mutations), maternal factors (including mutations in uterine receptivity genes and immune-related polymorphisms), and paternal factors (notably sperm DNA fragmentation and chromosomal abnormalities). In addition, maternal epigenetic modifications-particularly aberrant DNA methylation, histone alterations, and dysregulation of non-coding RNAs-along with environmental and lifestyle influences, play a critical role in modulating gene expression essential for endometrial receptivity and successful embryo implantation. This review highlights recent scientific advancements in understanding how genetic and epigenetic factors influence the implantation process. It additionally investigates their capability as biomarkers for diagnosis and as targets for novel therapeutic strategies. Comprehending these molecular mechanisms could aid in creating tailored fertility therapies and enhancing success rates for couples experiencing RIF.

Indexed as

Embryo ImplantationEpigenesis, GeneticPrecision MedicineReproductive MedicineDNA MethylationEmbryo TransferFemaleHumansMalePregnancyReproductive Techniques, AssistedCoding geneEndometrial receptivityEpigeneticsInfertilityNon-coding RNARecurrent implantation failure (RIF)Uterine immunological microenvironment

Identifiers

PMID41723324
PMCPMC13221556

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.