Evidence map›Paper›PMID 41723367›Full record

Observational studyBMC geriatrics2026

Companionship at hospital discharge and its association with subsequent delirium onset in older adults - the TRADE observational study.

Simone Brefka, Judith Adamo, Christoph Leinert, Johanna Braisch, Genia Decker, Rainer Muche, Thomas Seufferlein, Jochen Klaus, Lena Schulte-Kemna, Gerhard Eschweiler and 16 more

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Simone BrefkaInstitute for Geriatric Research, Ulm University Medical Center, Ulm, Germany. simone.brefka@agaplesion.de.
Judith AdamoInstitute for Psychogerontology, Friedrich-Alexander University Erlangen-Nuremberg, Nuremberg, Germany.
Christoph LeinertInstitute for Geriatric Research, Ulm University Medical Center, Ulm, Germany.
Johanna BraischInstitute for Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Genia DeckerInstitute for Geriatric Research, Ulm University Medical Center, Ulm, Germany.
Rainer MucheInstitute for Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Thomas SeufferleinDepartment of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
Jochen KlausDepartment of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
Lena Schulte-KemnaDepartment of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
Gerhard EschweilerGeriatric Center at University Hospital Tuebingen, Tuebingen, Germany.
Florian GebhardDepartment of Trauma-, Hand-, and Reconstructive Surgery, University Hospital Ulm, Ulm, Germany.
Konrad SchuetzeDepartment of Trauma-, Hand-, and Reconstructive Surgery, University Hospital Ulm, Ulm, Germany.
Tobias GeislerDepartment of Cardiology, University Hospital Tuebingen, Tuebingen, Germany.
Anke BahrmannDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany.
Hugo A KatusDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany.
Norbert FreyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany.
Natascha-Elisabeth DenningerDepartment for Primary Care and Health Services Research, Nursing Science and Interprofessional Care, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Martin MüllerDepartment for Primary Care and Health Services Research, Nursing Science and Interprofessional Care, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Kathrin PahmeierInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.
Janine Biermann-StallwitzInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.
Juergen WasemInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.
Anna Lena FlagmeierAOK - Allgemeine Ortskrankenkasse Baden-Wuerttemberg, Statutory Health Insurance Company, Stuttgart, Germany.
Petra BenzingerGeriatric Center, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Juergen BauerGeriatric Center, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Michael DenkingerInstitute for Geriatric Research, Ulm University Medical Center, Ulm, Germany.
Dhayana DallmeierInstitute for Geriatric Research, Ulm University Medical Center, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about the role of cross-sectoral companionship (CSC) at hospital discharge or transfer to another facility/department and subsequent delirium incidence in older adults. We aimed to identify predictors of optimal CSC, and to evaluate its association with delirium incidence after discharge/transfer in this population.

methodsParticipants aged ≥ 70 years and their caregivers were recruited in four hospitals in Germany from 08/2019 to 02/2020, and asked standardized questionnaires prior to as well as 3, 7 and 90 days after discharge/transfer. CSC was classified according to its occurrence: before, during and/or after discharge/transfer, defined as optimal when reported before and after or before, during and after. Incident delirium was identified by confusion assessment method (CAM), family-CAM (FAM-CAM) and nursing delirium screening scale (Nu-DESC) (composite outcome). Logistic regression was performed to identify predictors of optimal CSC, and to evaluate the association between CSC and delirium.

resultsAmong 163 participants (median age 80.8 years, 55.8% women) 61 (37.4%) reported optimal CSC, with social contact with daughter and son-in-law and length of hospital stay identified as positive, and former alcohol consumption and transport by ambulance as negative predictors. Among 92 participants (median age 81.6 years, 56.5% women) with complete data on the presence or absence of delirium a 20.7% [95% CI 13.6; 30.0] 7-days delirium incidence proportion was observed. No association between optimal CSC and subsequent delirium onset was detected.

conclusionOnly one third of patients reported optimal CSC at discharge/transfer, with social contact and length of hospital stay as positive, and former alcohol consumption and the use of an ambulance as negative predictors for an optimal CSC. Although no association between CSC and subsequent delirium could be identified in the present study, the fact that one fifth of discharged patients developed delirium highlights the importance of delirium-preventing measures around the time of discharge.

trial registrationDRKS (Deutsches Register klinischer Studien) DRKS00017828. Registered on 17th September 2019.

Indexed as

CaregiversDeliriumPatient DischargeAgedAged, 80 and overFemaleGermanyHumansIncidenceMaleCaregiverCompanionshipDeliriumDischargeFamilyOlder adultsTransfer

Identifiers

PMID41723367
PMCPMC12997767

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.