Evidence map›Paper›PMID 41723598›Full record

ArticleOncoimmunology2026

Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids.

Bianca M Balzasch, Andreas von Kries, Saskia Hüll, Indra A Shaltiel, Kim E Boonekamp, Volker Ast, Elke Burgermeister, Johannes Betge, Matthias Ebert, Michael Boutros and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bianca M BalzaschDepartment of Immunobiochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0009-0006-0038-4413
Andreas von KriesDepartment of Immunobiochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-7425-2329
Saskia HüllDepartment of Immunobiochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Indra A ShaltielDepartment of Immunobiochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-5673-6741
Kim E BoonekampGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.ORCID 0000-0002-9968-5382
Volker AstNGS Core Facility Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Elke BurgermeisterDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-4969-5697
Johannes BetgeDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0001-9549-1866
Matthias EbertDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Michael BoutrosGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.
Laura HelmingResearch Unit Oncology, EMD Serono, EMD Serono Research & Development Institute, Billerica, MA, USA.ORCID 0009-0005-6268-2101
Viktor UmanskyDKFZ-Hector Cancer Institute at the University Medical Center, Mannheim, Germany.ORCID 0000-0003-0259-1839
Adelheid CerwenkaDepartment of Immunobiochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) and monocytes that accumulate in colorectal cancer (CRC) play a crucial role in shaping the tumor microenvironment (TME) and anti-tumor immune responses. Although TAMs have been linked to both pro- and anti-tumor functions, our understanding of the cues instructing their heterogeneous phenotypes and function in cancer patients remains limited. Here, we established co-cultures comprising primary human monocytes and patient-derived organoids (PDOs) from patients with microsatellite-stable CRC to emulate myeloid/tumor cell interactions

Indexed as

Colonic NeoplasmsInterleukin-1betaMonocytesOrganoidsTumor-Associated MacrophagesCoculture TechniquesHumansTumor MicroenvironmentIL1B protein, humanInterleukin-1betacolon cancerIL1BOrganoidtumor-associated macrophages

Identifiers

PMID41723598
PMCPMC12928608

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.