Trial reportThe journal of nutrition, health & aging2026
Resistance training partially restores age-related differences in skeletal muscle amino acid transporters - secondary analysis from two randomized controlled trials.
Trial report in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Transcending aging: disease specificity, assessment challenges, and management strategies for rheumatoid arthritis-related sarcopenia.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePostprandial stimulation of muscle protein synthesis depends on intracellular amino acid (AA) availability and effective transmembrane AA transporters (AATs). AA transport may be impaired in sedentary and older adults. We compared skeletal muscle AATs between young and older adults and examined effects of resistance training combined with increased protein intake.
designSecondary analysis from two randomized controlled trials
settingParticipants were enrolled in trials comparing milk and native whey effects on anabolic signaling, muscle mass, and strength.
participantsHealthy young (n = 32; 14♀/18♂, 20-45 yrs) and older (n = 28; ♀/17♂, 70-80 yrs) adults
interventionWhole-body progressive resistance training 3×/week for 11-12 weeks with protein supplementation. MEASUREMENTS: Pre- and post-intervention assessments included lean leg mass (LLM), one-repetition maximum (1RM) leg press, and AAT protein levels in m. vastus lateralis biopsies. Western blots quantified L-Type Amino Acid Transporter 1 (LAT1) and 3 (LAT3), 4 F2 heavy chain (CD98) and solute carrier 38 member 9 (SNAT9) in cytosol (
resultsTraining increased LLM by ∼1 kg and 1RM leg press by ∼31% in both groups (p < 0.001). At baseline, older adults showed higher SNAT9
conclusionResistance training with protein supplementation improved muscle mass and strength and modified AAT profiles. Age was associated with higher membrane LAT1 and SNAT9, while training attenuated some age-related differences and produced distinct effects on LAT3 and CD98 by age. Exercise may partially counteract age-related alterations in muscle AA transport, with implications for muscle health in aging.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.