Evidence map›Paper›PMID 41724258›Full record

ArticleInternational journal of pharmaceutics2026

Topical administration of in situ gelling formulation containing myricetin-polycarboxylate nanoparticles inhibits murine genital herpes infection.

Sudipta Mallick, Pankaj Sharma, Tejabhiram Yadavalli, Ram Koganti, Sudhanshu Kumar Singh, Kailee Yoshimura, Divya Kapoor, Yogesh Sutar, Joseph S Adams, Manjusha Annaji and 2 more

Abstract read
In one paragraph

Article in International journal of pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sudipta MallickDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii Hilo, Hilo, HI 96720, USA; Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA.
Pankaj SharmaDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Tejabhiram YadavalliDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Ram KogantiDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Sudhanshu Kumar SinghDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Kailee YoshimuraDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii Hilo, Hilo, HI 96720, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Divya KapoorDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Yogesh SutarDepartment of Pharmacology and Toxicology, R. K. Coit College of Pharmacy, University Arizona, Tucson, AZ 85721, USA.
Joseph S AdamsDepartment of Pharmacology and Toxicology, R. K. Coit College of Pharmacy, University Arizona, Tucson, AZ 85721, USA.
Manjusha AnnajiDepartment of Pharmacology and Toxicology, R. K. Coit College of Pharmacy, University Arizona, Tucson, AZ 85721, USA.
Deepak ShuklaDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: dshukla@uic.edu.
Abhijit A DateDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii Hilo, Hilo, HI 96720, USA; Department of Pharmacology and Toxicology, R. K. Coit College of Pharmacy, University Arizona, Tucson, AZ 85721, USA; Department of Ophthalmology and Vision Science, University of Arizona College of Medicine, Tucson, AZ 85711, USA. Electronic address: abhijitdate@arizona.edu.

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 1985 to 2025
$14.8M
Alleviation of ER stress as a translational strategy to curb ocular viral infectionsR24EY033598 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Abhijit A Date, DEEPAK SHUKLA · 2022 to 2026
$5.4M
A new molecular therapy against ocular herpesR01EY024710 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DEEPAK SHUKLA · 2015 to 2026
$5.2M
Repurposing and reformulation of adefovir dipivoxil for improved topical treatment of herpes simplex virus infection of the eyeR01EY036247 · NEI · UNIVERSITY OF ARIZONA · PI Abhijit A Date, DEEPAK SHUKLA · 2024 to 2026
$1.9M
A small molecule inhibitor of HSV genital infectionsR01AI139768 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 2018 to 2021
$1.6M
Ionic Liquids of tenofovir prodrugs for improved oral bioavailability and antiviral efficacyR21AI176907 · NIAID · UNIVERSITY OF ARIZONA · PI DATE, ABHIJIT A · 2023 to 2024
$437k
Ionic liquid-based nanoemulsion containing combination antiretroviral drugs forthe transdermal treatment of pediatric HIV infectionR21AI184072 · NIAID · UNIVERSITY OF ARIZONA · PI DATE, ABHIJIT A · 2024 to 2025
$415k
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY024710NEI NIH HHS R01 EY036247NEI NIH HHS R24 EY033598NIAID NIH HHS R01 AI139768NIAID NIH HHS R21 AI176907NIAID NIH HHS R21 AI184072
6 · The paper itself

Abstract

Genital herpes (GH) is a persistent sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2). Recently, myricetin (MYR), a natural flavonoid with low aqueous solubility, was shown to target HSV gD protein. Here, using computational tools, we showed that MYR forms a stable complex with HSV gD protein. MYR was well tolerated by HeLa cells (CC

Indexed as

Antiviral AgentsFlavonoidsHerpes GenitalisNanoparticlesAdministration, TopicalAnimalsFemaleGelsHeLa CellsHerpesvirus 2, HumanHumansMiceMice, Inbred BALB CSolubilityAntiviral AgentsFlavonoidsGelsmyricetinEudragitHPMCPMyricetinPoloxamer 407PVAPSTI

Identifiers

PMID41724258
PMCPMC13215639

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.